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Phloretin and phloridzin guard against cisplatin-induced nephrotoxicity in mice through inhibiting oxidative stress and inflammation

Harun Ün, Rüstem Anıl Uğan, Muhammet Ali Gürbüz, Yasin Bayır, Aysenur Kahramanlar, Gokce Kaya, Elif Çadırcı, Zekai Halıcı

Life sciences Cilt 266 · 01.02.2021
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Özet

Aim: Cisplatin (Cis) is widely used chemotherapeutic and has some serious side effects as nephrotoxicity. Phloretin (PH) and Phloridzin (PZ) are known their anti-oxidant anti-inflammatory effects. We aimed to examine the protective effects of PH and PZ on cisplatin-induced nephrotoxicity.

Anahtar kelimeler

TISSUE EFFICACY mice toxicity ASSAY antioxidant kidney INJURY cisplatin nephrotoxicity Phloretin Phloridzin MAMMALIAN-CELLS HEAT-SHOCK-PROTEIN-70 INCREASES

Sürdürülebilir Kalkınma Amaçları

  • SKA 3: Sağlıklı Bireyler

Atıf için künye

Ün, H., Uğan, R. A., Gürbüz, M. A., Bayır, Y., Kahramanlar, A., Kaya, G., Çadırcı, E., & Halıcı, Z. (2021). Phloretin and phloridzin guard against cisplatin-induced nephrotoxicity in mice through inhibiting oxidative stress and inflammation. Life sciences, 266. https://doi.org/10.1016/j.lfs.2020.118869

BibTeX 
@article{un2021-23666,
  author = {Ün, Harun and Uğan, Rüstem Anıl and Gürbüz, Muhammet Ali and Bayır, Yasin and Kahramanlar, Aysenur and Kaya, Gokce and Çadırcı, Elif and Halıcı, Zekai},
  title = {Phloretin and phloridzin guard against cisplatin-induced nephrotoxicity in mice through inhibiting oxidative stress and inflammation},
  journal = {Life sciences},
  year = {2021},
  volume = {266},
  issn = {0024-3205},
  doi = {10.1016/j.lfs.2020.118869},
  url = {https://akademik.atauni.edu.tr/yayinlar/23666-phloretin-and-phloridzin-guard-against-cisplatin-induced-nephrotoxicity-in-mice}
}