Multiple organ dysfunction syndrome in pediatric colchicine poisoning: a national cohort study from Türkiye
Özet
Background/aim: Colchicine poisoning has been associated with systemic toxicity, multiple organ dysfunction syndrome (MODS), and mortality. In the present study, the demographic, clinical, and laboratory characteristics of pediatric colchicine poisoning cases and the incidence of organ failure are investigated to identify potential risk factors associated with MODS. Materials and methods: Included in this retrospective multicenter cohort study were pediatric patients admitted to 28 tertiary-care pediatric intensive care units with a diagnosis of colchicine poisoning. Demographic data, clinical and laboratory findings, and clinical outcomes were extracted from medical records. MODS was defined as dysfunction involving at least two organ systems. Multivariable logistic regression analysis was performed to identify the variables independently associated with MODS. Results: Of the 150 patients included in the study, 40% were younger than 5 years and 52% were older than 13 years. Gastrointestinal symptoms were most prominent, with nausea and vomiting observed in 64.7%, abdominal pain in 36.7%, and diarrhea in 24%. Overall, 66% developed no organ failure, while single-organ failure occurred in 7.3% and 26.7% developed MODS. The coagulation system was most frequently affected (26%), followed by the hematological (19.3%) and immunological (18%) systems. Multivariable logistic regression analysis identified the baseline PRISM III score, ingested colchicine dose per kilogram of body weight, and initial sodium, creatinine, and aspartate aminotransferase (AST) levels as independent predictors of MODS. Conclusion: MODS can develop at ingestion doses lower than 0.5 mg/kg, which have historically been considered safe. Higher ingested doses and elevated PRISM III scores were associated with MODS, although these findings are derived from retrospective observational data and should not be interpreted as causal or as direct clinical recommendations. Further prospective studies are needed to clarify relevant doses, interventions, and prognostic factors in pediatric colchicine poisoning associated with MODS.
Anahtar kelimeler
Atıf için künye
EKİNCİ, F., YILDIZDAŞ, R. D., Horoz, Ö. Ö., YILMAZ, H. L., BİLEN, S., ÜNAL, İ., Türker, İ., Şevketoğlu, E., Akçay, N., ÇITAK, A., ŞIK, S. G., KENDİRLİ, T., HAVAN, M., Kangin, M., Talay, M. N., Yener, N., Albayrak, H., Botan, E., Özer, U., … Öztürk, Z. (2026). Multiple organ dysfunction syndrome in pediatric colchicine poisoning: a national cohort study from Türkiye. TURKISH JOURNAL OF MEDICAL SCIENCES, 56(3), 708–717. https://doi.org/10.55730/1300-0144.6204
BibTeX
@article{ekinci2026-236475,
author = {EKİNCİ, FARUK and YILDIZDAŞ, RIZA DİNÇER and Horoz, Özden Özgür and YILMAZ, HAYRİ LEVENT and BİLEN, SEVCAN and ÜNAL, İLKER and Türker, İkbal and Şevketoğlu, Esra and Akçay, Nihal and ÇITAK, AGOP and ŞIK, SARE GÜNTÜLÜ and KENDİRLİ, TANIL and HAVAN, MERVE and Kangin, Murat and Talay, Mehmet Nur and Yener, Nazik and Albayrak, Hatice and Botan, Edin and Özer, Utku and Oto, Arzu and Bozan, Gürkan and Duyu, Muhterem and Akyıldız, Başak Nur and Gökay, Naime and Çelik, Elif and Konca, Çapan and Yazıcı, Mutlu Uysal and Dursun, Oğuz and Girgin, Feyza İnceköy and Arı, Hatice Feray and Arslan, İlknur and Özkale, Murat and Sandal, Özlem and Mısırlıoğlu, Merve and Keskin, Halil and Kaya, Sadık and Kılınç, Arda and Sarı, Ferhat and Akın, Fatih and Aşık, Ayşe and Bingöl, İbrahim and Turanlı, Eda and Boyraz, Merve and DİNLEYİCİ, ENER ÇAĞRI and Dündar, Mehmet Akif and Özcan, Selver Ceren and Akıllı, Aygül Kaya and Akkuzu, Emine and ÜLGEN TEKEREK, NAZAN and Öztürk, Nilüfer and Gün, Emrah and Özkale, Yasemin and Kutlu, Nurettin Onur and Öztürk, Zeynelabidin},
title = {Multiple organ dysfunction syndrome in pediatric colchicine poisoning: a national cohort study from Türkiye},
journal = {TURKISH JOURNAL OF MEDICAL SCIENCES},
year = {2026},
volume = {56},
number = {3},
pages = {708--717},
issn = {1300-0144},
doi = {10.55730/1300-0144.6204},
url = {https://akademik.atauni.edu.tr/yayinlar/236475-multiple-organ-dysfunction-syndrome-in-pediatric-colchicine-poisoning-a-national}
}