Effects of Administration of Amlodipine and Lacidipine on Inflammation-Induced Bone Loss in the Ovariectomized Rat

Karakus, Emre; Halıcı, Zekai; Albayrak, Abdulmecit; Bayır, Yasin; Demirci, Elif; Aydın, Ali; Ozturk-Karagoz, Berna; Çadırcı, Elif; Ayan, Arif Kursat; Şahin, Ali; Unal, Deniz

doi:10.1007/s10753-015-0254-6

Makale Tam Makale Uluslararası 2016

Effects of Administration of Amlodipine and Lacidipine on Inflammation-Induced Bone Loss in the Ovariectomized Rat

Emre Karakus, Zekai Halıcı, Abdulmecit Albayrak, Yasin Bayır, Elif Demirci, Ali Aydın, Berna Ozturk-Karagoz, Elif Çadırcı, Arif Kursat Ayan, Ali Şahin, Deniz Unal

INFLAMMATION Cilt 39 · Sayı 1 · ss. 336–346 · 01.02.2016

DOI ile aç

Özet

This study was performed to evaluate the possible protective effect of two calcium channel blocker's "lacidipine (LAC) and amlodipine (AML)" on bone metabolism in an experimental ovariectomized and inflammation-induced osteoporosis rat model (OVXinf). For the purpose of this study, the rats were divided into eight groups, each containing eight rats: sham-operated control (group 1, SH), sham + inflammation (group 2, SHinf), ovariectomy (group 3, OVX), ovariectomy + inflammation (group 4, OVXinf), ovariectomy + LAC 4 mg/kg (group 5, OVX + LAC), ovariectomy + inflammation + LAC 4 mg/kg (group 6, OVXinf + LAC), ovariectomy + AML 5 mg/kg (group 7, OVX + AML), ovariectomy + inflammation + AML 5 mg/kg (group 8, OVXinf + AML). The levels of osteocalcin and osteopontin decreased in OVXinf + LAC and OVXinf + AML groups. The serum levels of TNF-alpha, IL-1 beta, and IL-6 were increased significantly in the OVXinf rats compared with the SH group. Gene expression levels of the osteogenic factor runt-related transcription factor 2 (Runx2) and type I collagen 1A1 (Col1A1) significantly decreased in the OVXinf group, when compared with the control group. AML or LAC administrations increased the levels of Runx2 and Col1A1. These results suggest that amlodipine and lacidipine may be a novel therapeutic target for radical osteoporosis treatment in hypertensive patients.

Anahtar kelimeler

BONE-MINERAL DENSITY oxidative stress NITRIC-OXIDE INFLAMMATION TNF-ALPHA Lacidipine amlodipine ovariectomized rat MARROW STROMAL CELLS SP1 BINDING-SITE POSTMENOPAUSAL OSTEOPOROSIS INOSITOL TRISPHOSPHATE COLLAGEN GENES DEFICIENT MICE CA2+ RELEASE

Atıf için künye

Karakus, E., Halıcı, Z., Albayrak, A., Bayır, Y., Demirci, E., Aydın, A., Ozturk-Karagoz, B., Çadırcı, E., Ayan, A. K., Şahin, A., & Unal, D. (2016). Effects of Administration of Amlodipine and Lacidipine on Inflammation-Induced Bone Loss in the Ovariectomized Rat. INFLAMMATION, 39(1), 336–346. https://doi.org/10.1007/s10753-015-0254-6

BibTeX

@article{karakus2016-23618,
  author = {Karakus, Emre and Halıcı, Zekai and Albayrak, Abdulmecit and Bayır, Yasin and Demirci, Elif and Aydın, Ali and Ozturk-Karagoz, Berna and Çadırcı, Elif and Ayan, Arif Kursat and Şahin, Ali and Unal, Deniz},
  title = {Effects of Administration of Amlodipine and Lacidipine on Inflammation-Induced Bone Loss in the Ovariectomized Rat},
  journal = {INFLAMMATION},
  year = {2016},
  volume = {39},
  number = {1},
  pages = {336--346},
  issn = {0360-3997},
  doi = {10.1007/s10753-015-0254-6},
  url = {https://akademik.atauni.edu.tr/yayinlar/23618-effects-of-administration-of-amlodipine-and-lacidipine-on-inflammation-induced}
}