The assessment of genotoxic effects in lymphocyte cultures of infants treated with chloral hydrate
Özet
Chloral hydrate is a sedative commonly used in pediatric medicine. It was evaluated for genotoxicity in cultured peripheral blood lymphocytes of infants who were given chloral hydrate for sedation. Sister chromatid exchange and micronucleus frequencies were determined before and after chloral hydrate administration. After treatment, the frequencies of sister chromatid exchange and micronuclei were significantly increased, suggesting that chloral hydrate has moderate genotoxic potential in infants. (C) 2004 Elsevier B.V. All rights reserved.
Anahtar kelimeler
Atıf için künye
İKBAL, M., TAŞTEKİN, A., Doğan, H., Pirim, İ., & ÖRS, R. (2004). The assessment of genotoxic effects in lymphocyte cultures of infants treated with chloral hydrate. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 564(2), 159–164. https://doi.org/10.1016/j.mrgentox.2004.08.007
BibTeX
@article{ikbal2004-235869,
author = {İKBAL, MEVLİT and TAŞTEKİN, AYHAN and Doğan, Hasan and Pirim, İbrahim and ÖRS, RAHMİ},
title = {The assessment of genotoxic effects in lymphocyte cultures of infants treated with chloral hydrate},
journal = {MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS},
year = {2004},
volume = {564},
number = {2},
pages = {159--164},
issn = {1383-5718},
doi = {10.1016/j.mrgentox.2004.08.007},
url = {https://akademik.atauni.edu.tr/yayinlar/235869-the-assessment-of-genotoxic-effects-in-lymphocyte-cultures-of-infants-treated}
}