Hepatoprotective Effect of 17 beta-Estradiol as Antioxidant Modulators Against Stress Damage

Can, S; Cıgsar, G; Gür, Fatma; Aksak, Karamese; Sellı, Jale; Bacak, G; Gedikli, Semin; Sahın, Gz; Yıgıt, Serdar; Can, İ; Gül, Mustafa

doi:10.5812/hepatmon.22633

Makale Tam Makale Uluslararası 2015

Hepatoprotective Effect of 17 beta-Estradiol as Antioxidant Modulators Against Stress Damage

S Can, G Cıgsar, Fatma Gür, Karamese Aksak, Jale Sellı, G Bacak, Semin Gedikli, Gz Sahın, Serdar Yıgıt, İ Can, Mustafa Gül

Hepatitis Monthly Cilt 15 · Sayı 2 · 01.02.2015

DOI ile aç

Özet

Background: Liver is one of the most important organs affected by exercise. According to the literature a few study to date has investigated the effects of estrogen supplementation on exercise-induced oxidative stress in liver tissue of rats.

Objectives: We aimed to investigate the effects of estrogen supplementation on oxidative stress markers in liver tissue of exercised rats.

Materials and Methods: Male rats (n = 35) were divided as estrogen supplemented (n = 18) and non-supplemented groups (n = 17); these groups were further divided as rest and eccentric exercised groups. Eccentric exercise groups were further divided as rats killed after 1 hour and 48 hours of eccentric exercise. Estrogen (10 mg/kg) was administered subcutaneously for 30 days. Eccentric exercise was applied as treadmill run (15° downhill, 20 m/min) consisting of periods of 5 min run and 2 min rest repeated 18 times. The rat liver was examined biochemically and histologically. Activities of GST, GSH-Px, CAT, SOD and MDA concentration were also measured spectrophotometrically.

Results: Some disruptions were detected in experimental groups compared with the control group. Additionally, exercise training caused an increase in SOD and decrease in GSH-Px activities in some experimental groups. SOD activities increased significantly in group 3 (Estrogen (-), eccentric exercise (+) killed (after 1 h), compared with group 5 (Estrogen (-), eccentric exercise (+) killed (after 48 h). On the other hand, GSH-Px activities were also significantly decreased in groups 3, 4 and 5 compared with the control group. Leukocyte infiltration in liver increased after 48 hours compared with after 1 hour and estrogen supplementation was not able to prevent this infiltration.

Conclusions: Estrogen seemed to be not very effective to prevent eccentric exercise-induced liver damage.

Anahtar kelimeler

oxidative stress ACID ANTIOXIDANTS exercise liver Estrogen ESTROGENS ESTRADIOL METABOLISM SKELETAL-MUSCLE neutrophil infiltration INCREASES period EXERCISE-INDUCED MUSCLE

Atıf için künye

Can, S., Cıgsar, G., Gür, F., Aksak, K., Sellı, J., Bacak, G., Gedikli, S., Sahın, G., Yıgıt, S., Can, İ., & Gül, M. (2015). Hepatoprotective Effect of 17 beta-Estradiol as Antioxidant Modulators Against Stress Damage. Hepatitis Monthly, 15(2). https://doi.org/10.5812/hepatmon.22633

BibTeX

@article{can2015-234570,
  author = {Can, S and Cıgsar, G and Gür, Fatma and Aksak, Karamese and Sellı, Jale and Bacak, G and Gedikli, Semin and Sahın, Gz and Yıgıt, Serdar and Can, İ and Gül, Mustafa},
  title = {Hepatoprotective Effect of 17 beta-Estradiol as Antioxidant Modulators Against Stress Damage},
  journal = {Hepatitis Monthly},
  year = {2015},
  volume = {15},
  number = {2},
  issn = {1735-143X},
  doi = {10.5812/hepatmon.22633},
  url = {https://akademik.atauni.edu.tr/yayinlar/234570-hepatoprotective-effect-of-17-beta-estradiol-as-antioxidant-modulators-against}
}