Protective effect of T-type calcium channel blocker in histamine-induced paw inflammation in rat
Özet
The aim of this paper was to investigate the protective effect of the T-type calcium channel blocker in a model of acute local inflammation (histamine-induced). The intraplantar injection of histamine elicited an inflammatory response that was characterized by a time-dependent increase in paw oedema and neutrophil infiltration in paw tissue. The maximal increase in paw volume was observed at 90 min after histamine administration (maximal paw volume: 0.97 +/- 0.07). In addition, polymorphonuclear leucocyte (PNL) number was markedly increased in the histamine-treated paw tissue (144 +/- 25.56). However, histamine-induced paw oedema was significantly reduced in a dose-dependent manner by treatment with mibefradil (given at 10, 25, 50, and 100 mg kg(-1)) at 30, 60, 90, 120, 150, 180 min after injection of histamine. Mibefradil treatment also caused a significant reduction of the polymorphonuclear leucocyte number in the paw tissue. Our findings support the view that mibefradil exerts antiinflammatory effects. (C) 2001 Academic Press.
Atıf için künye
Bilici, D., Akpınar, E., Gursan, N., Dengiz, G., Bilici, S., & Altas, S. (2001). Protective effect of T-type calcium channel blocker in histamine-induced paw inflammation in rat. Pharmacological research, 44(6), 527–531. https://doi.org/10.1006/phrs.2001.0877
BibTeX
@article{bilici2001-233268,
author = {Bilici, D and Akpınar, Erol and Gursan, N and Dengiz, GO and Bilici, S and Altas, S},
title = {Protective effect of T-type calcium channel blocker in histamine-induced paw inflammation in rat},
journal = {Pharmacological research},
year = {2001},
volume = {44},
number = {6},
pages = {527--531},
issn = {1043-6618},
doi = {10.1006/phrs.2001.0877},
url = {https://akademik.atauni.edu.tr/yayinlar/233268-protective-effect-of-t-type-calcium-channel-blocker-in-histamine-induced-paw}
}