Preliminary investigation of gene expression levels of PAPP-A, STC-2, and HIF-1 alpha in SARS-Cov-2 infected patients

Uzuncakmak, Sevgi Karabulut; Naldan, Muhammet Emin; Dirican, Ebubekir; Kerget, Ferhan; Halıcı, Zekai

doi:10.1007/s11033-022-07710-9

Makale Tam Makale Uluslararası 2022 Açık erişimli

Preliminary investigation of gene expression levels of PAPP-A, STC-2, and HIF-1 alpha in SARS-Cov-2 infected patients

Sevgi Karabulut Uzuncakmak, Muhammet Emin Naldan, Ebubekir Dirican, Ferhan Kerget, Zekai Halıcı

MOLECULAR BIOLOGY REPORTS Cilt 49 · Sayı 9 · ss. 8693–8699 · 01.09.2022

DOI ile aç

Özet

Background Coronavirus-19 is still considered a pandemic that influences the world. Other molecular alterations should be clearer besides the increasing cytokine storm and pro-inflammatory molecules. Hypoxic conditions that induce HIF-1 alpha lead to stimulate gene expression of STC-2 that targets PAPP-A expression. This study aimed to determine gene expression levels of PAPP-A, STC-2, and HIF-1 alpha in COVID-19 infection. We also aimed to reveal the relationship of these genes with laboratory and clinical data of COVID-19 patients.

Anahtar kelimeler

CELLS GROWTH COVID-19 SARS-CoV-2 INHIBITION TARGET PAPP-A HIF-1 MOUSE HIF-1 alpha BINDING-PROTEIN 4 STC-2 PLASMA-PROTEIN-A HYPOXIA-INDUCIBLE FACTOR STANNIOCALCIN-2

Sürdürülebilir Kalkınma Amaçları

SKA 3: Sağlıklı Bireyler

Atıf için künye

Uzuncakmak, S. K., Naldan, M. E., Dirican, E., Kerget, F., & Halıcı, Z. (2022). Preliminary investigation of gene expression levels of PAPP-A, STC-2, and HIF-1 alpha in SARS-Cov-2 infected patients. MOLECULAR BIOLOGY REPORTS, 49(9), 8693–8699. https://doi.org/10.1007/s11033-022-07710-9

BibTeX

@article{uzuncakmak2022-232936,
  author = {Uzuncakmak, Sevgi Karabulut and Naldan, Muhammet Emin and Dirican, Ebubekir and Kerget, Ferhan and Halıcı, Zekai},
  title = {Preliminary investigation of gene expression levels of PAPP-A, STC-2, and HIF-1 alpha in SARS-Cov-2 infected patients},
  journal = {MOLECULAR BIOLOGY REPORTS},
  year = {2022},
  volume = {49},
  number = {9},
  pages = {8693--8699},
  issn = {0301-4851},
  doi = {10.1007/s11033-022-07710-9},
  url = {https://akademik.atauni.edu.tr/yayinlar/232936-preliminary-investigation-of-gene-expression-levels-of-papp-a-stc-2-and-hif-1}
}