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Makale Tam Makale Uluslararası 2022

Cerebrolysin Alleviating Effect on Glutamate-Mediated Neuroinflammation Via Glutamate Transporters and Oxidative Stress

Seydanur Avci, Sukran Gunaydin, NEZİHA SENEM KURTCAN, Emine Karaca Sulukoglu, Özlem Erol Polat, Ibrahim Gecili, Yeşim YENİ, Aysegul Yilmaz, Sidika Genc, Ahmet Hacımüftüoğlu, Serkan Yıldırım, Muhammed Yasser Mokresh, Damla Gul Findik, Aristidis Tsatsakis, Denisa Margina, Konstantinos Tsarouhas, David R. Wallace, Ali Taghizadehghalehjoughi

JOURNAL OF MOLECULAR NEUROSCIENCE Cilt 72 · Sayı 11 · ss. 2292–2302 · 01.11.2022
DOI ile aç

Özet

Glutamate, one of the most important excitatory neurotransmitters, acts as a signal transducer in peripheral tissues and endocrine cells. Excessive glutamate secretion has been shown to cause excitotoxicity and neurodegenerative disease. Cerebrolysin is a mixture of enzymatically treated peptides derived from pig brain including neurotrophic factors, like brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF), and ciliary neurotrophic factor (CNTF). The present study investigated the protective effects of cerebrolysin on glutamate transporters (EAAT 1, EAAT 2) and cytokines (IL-1 beta and IL-10) activity in glutamate-mediated neurotoxicity. Primary cortex neuron culture was exposed to glutamate and successively treated with various cerebrolysin concentrations for 24 and 48 h. Our data showed that cerebrolysin primarily protects neurons by decreasing glutamate concentration in the synaptic cleft. In addition, Cerebrolysin can decrease oxidative stress and neuron cell damage by increasing antioxidant activity and decreasing inflammation cytokine levels.

Anahtar kelimeler

DISEASE glutamate IL-1 beta LDH IL-10 EAAT 1 EAAT 2

Sürdürülebilir Kalkınma Amaçları

  • SKA 3: Sağlıklı Bireyler

Atıf için künye

Avci, S., Gunaydin, S., KURTCAN, N. S., Sulukoglu, E. K., Erol Polat, Ö., Gecili, I., YENİ, Y., Yilmaz, A., Genc, S., Hacımüftüoğlu, A., Yıldırım, S., Mokresh, M. Y., Findik, D. G., Tsatsakis, A., Margina, D., Tsarouhas, K., Wallace, D. R., & Taghizadehghalehjoughi, A. (2022). Cerebrolysin Alleviating Effect on Glutamate-Mediated Neuroinflammation Via Glutamate Transporters and Oxidative Stress. JOURNAL OF MOLECULAR NEUROSCIENCE, 72(11), 2292–2302. https://doi.org/10.1007/s12031-022-02078-8

BibTeX 
@article{avci2022-232229,
  author = {Avci, Seydanur and Gunaydin, Sukran and KURTCAN, NEZİHA SENEM and Sulukoglu, Emine Karaca and Erol Polat, Özlem and Gecili, Ibrahim and YENİ, Yeşim and Yilmaz, Aysegul and Genc, Sidika and Hacımüftüoğlu, Ahmet and Yıldırım, Serkan and Mokresh, Muhammed Yasser and Findik, Damla Gul and Tsatsakis, Aristidis and Margina, Denisa and Tsarouhas, Konstantinos and Wallace, David R. and Taghizadehghalehjoughi, Ali},
  title = {Cerebrolysin Alleviating Effect on Glutamate-Mediated Neuroinflammation Via Glutamate Transporters and Oxidative Stress},
  journal = {JOURNAL OF MOLECULAR NEUROSCIENCE},
  year = {2022},
  volume = {72},
  number = {11},
  pages = {2292--2302},
  issn = {0895-8696},
  doi = {10.1007/s12031-022-02078-8},
  url = {https://akademik.atauni.edu.tr/yayinlar/232229-cerebrolysin-alleviating-effect-on-glutamate-mediated-neuroinflammation-via}
}