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Makale Tam Makale Uluslararası 2019

Ameliorative effect of gossypin against acute lung injury in experimental sepsis model of rats

Irfan Cinar, Busra Sirin, Pelin Aydin, Erdem TOKTAY, Elif Çadırcı, Iclal Halici, Zekai Halıcı

Life sciences Cilt 221 · ss. 327–334 · 15.03.2019
DOI ile aç

Özet

Aims: Sepsis is a complex pathophysiological event involving systemic inflammatory response syndrome, multiple organ dysfunction syndrome and tissue damage such as acute lung injury (ALI). Although many new mechanisms are being investigated to enlighten the pathophysiology of sepsis, there is no effective treatment protocol yet. Antioxidant, antibacterial and antiinflammatory effects of gossypin (GOS)-like flavonoids have been shown and we have hypothesized that GOS have roles in sepsis induced inflammation of lungs.

Anahtar kelimeler

LIPID-PEROXIDATION KAPPA-B alpha lipoic acid GENE-EXPRESSION ISCHEMIA-REPERFUSION INJURY CLP Lung injury NF-KAPPA-B CECAL LIGATION PROTEIN SEPTIC SHOCK Gossypin NLRP3 HMGB1 HMG beta 1 RECEPTOR 4

Atıf için künye

Cinar, I., Sirin, B., Aydin, P., TOKTAY, E., Çadırcı, E., Halici, I., & Halıcı, Z. (2019). Ameliorative effect of gossypin against acute lung injury in experimental sepsis model of rats. Life sciences, 221, 327–334. https://doi.org/10.1016/j.lfs.2019.02.039

BibTeX 
@article{cinar2019-231964,
  author = {Cinar, Irfan and Sirin, Busra and Aydin, Pelin and TOKTAY, Erdem and Çadırcı, Elif and Halici, Iclal and Halıcı, Zekai},
  title = {Ameliorative effect of gossypin against acute lung injury in experimental sepsis model of rats},
  journal = {Life sciences},
  year = {2019},
  volume = {221},
  pages = {327--334},
  issn = {0024-3205},
  doi = {10.1016/j.lfs.2019.02.039},
  url = {https://akademik.atauni.edu.tr/yayinlar/231964-ameliorative-effect-of-gossypin-against-acute-lung-injury-in-experimental-sepsis}
}