Alpha-Lipoic Acid Protects against Indomethacin-Induced Gastric Oxidative Toxicity by Modulating Antioxidant System
Özet
Gastroprotective effects of alpha-lipoic acid (ALA) against oxidative gastric damage induced by indomethacin (IND) have been investigated. All doses (50, 75, 100, 150, 200, and 300 mg/kg body weight) of ALA reduced the ulcer index with 88.2% to 96.1% inhibition ratio. In biochemical analyses of stomach tissues, ALA administration decreased the level of lipid peroxidation (LPO) and activities of myeloperoxidase (MPO) and catalase (CAT) in gastric tissues, which were increased after IND application. ALA also increased the level of glutathione (GSH) and activities of superoxide dismutase (SOD) and glutathione S-transferase (GST) that were decreased in gastric damaged stomach tissues. In conclusion, the gastroprotective effect of ALA could be attributed to its ameliorating effect on the antioxidant defense systems.
Anahtar kelimeler
Atıf için künye
Kaplan, K. A., Odabasoglu, F., Halıcı, Z., Halıcı, M. B., Çadırcı, E., Atalay, F., Aydin, O., & Cakir, A. (2012). Alpha-Lipoic Acid Protects against Indomethacin-Induced Gastric Oxidative Toxicity by Modulating Antioxidant System. JOURNAL OF FOOD SCIENCE, 77(11). https://doi.org/10.1111/j.1750-3841.2012.02920.x
BibTeX
@article{kaplan2012-231963,
author = {Kaplan, Kursat Ali and Odabasoglu, Fehmi and Halıcı, Zekai and Halıcı, Mesut Bünyami and Çadırcı, Elif and Atalay, Fadime and Aydin, Ozlem and Cakir, Ahmet},
title = {Alpha-Lipoic Acid Protects against Indomethacin-Induced Gastric Oxidative Toxicity by Modulating Antioxidant System},
journal = {JOURNAL OF FOOD SCIENCE},
year = {2012},
volume = {77},
number = {11},
issn = {0022-1147},
doi = {10.1111/j.1750-3841.2012.02920.x},
url = {https://akademik.atauni.edu.tr/yayinlar/231963-alpha-lipoic-acid-protects-against-indomethacin-induced-gastric-oxidative}
}