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Gastroprotective and Antioxidant Effects of the Cinnamon, Cumin, Sumac on Indomethacin Induced Gastric Ulcer in Rats

Özlem Aydın Berktaş, Fehmi Odabaşoğlu, Fadime Atalay Dumlu, Zerrin Kutlu, Elif Çadırcı, Mesut Bünyami Halıcı, Fazlı Öztürk, Ahmet Çakır

Eurasian Journal of Food Science and Technology Cilt 5 · Sayı 2 · ss. 147–166 · 01.12.2021

Özet

The gastro-protective effect of water extracts spice of cinnamon, cumin and sumac in

indomethacin induced ulcer model in rats was investigated, in vivo and biochemical

mechanism of spice extracts were monitored by measuring their antioxidant. For each cumin,

cinnamon and sumach extracts 50, 100, 200 and 400 mg/kg, positive control famotidine (FAM)

25 mg/kg and negative control indomethacin (IND) 25 mg/kg dosage form was orally

administered. After that catalase (CAT), superoxide dismutase (SOD), myeloperoxidase (MPx)

enzyme activities and glutathione (GSH), lipid perxidase (LPO) amounts were measured. In

IND induced ulcer group, It is determined that each four dosage form of spices and positive

control FAM group significantly decreased the ulcer area (p<0.05). In addition to this, CAT,

SOD, MPx enzyme activities and GSH, LPO amounts were measured in spice extract

administered gastric damaged rat stomach tissues in order to explain the effects of antioxidant

defense system on antiulcerogenic activity. In IND induced tissues, while LPO, MPx and CAT

increased GSH and SOD decreased with respect to the (healthy) control group. It is claimed by

the measured enzyme activity differences that these spices have antiulcerogenic activity.

Atıf için künye

Aydın Berktaş, Ö., Odabaşoğlu, F., Atalay Dumlu, F., Kutlu, Z., Çadırcı, E., Halıcı, M. B., Öztürk, F., & Çakır, A. (2021). Gastroprotective and Antioxidant Effects of the Cinnamon, Cumin, Sumac on Indomethacin Induced Gastric Ulcer in Rats. Eurasian Journal of Food Science and Technology, 5(2), 147–166. https://dergipark.org.tr/tr/pub/ejfst/issue/67811/958381

BibTeX 
@article{aydinberktas2021-231962,
  author = {Aydın Berktaş, Özlem and Odabaşoğlu, Fehmi and Atalay Dumlu, Fadime and Kutlu, Zerrin and Çadırcı, Elif and Halıcı, Mesut Bünyami and Öztürk, Fazlı and Çakır, Ahmet},
  title = {Gastroprotective and Antioxidant Effects of the Cinnamon, Cumin, Sumac on Indomethacin Induced Gastric Ulcer in Rats},
  journal = {Eurasian Journal of Food Science and Technology},
  year = {2021},
  volume = {5},
  number = {2},
  pages = {147--166},
  issn = {2667-4890},
  url = {https://akademik.atauni.edu.tr/yayinlar/231962-gastroprotective-and-antioxidant-effects-of-the-cinnamon-cumin-sumac-on}
}