Evaluation of 5-HT7 receptor expression in the placentae of normal and pre-eclamptic women
Özet
In this study, by examining 5-HT7 receptor expression in placentae from pre-eclamptic and normal pregnancies, we aimed to discover a new step of pathophysiological cascade for preeclampsia. Patients whose blood pressure over the 140/90 mmHg were included when study after 20 weeks of gestation. 5-HT7 receptor expression was investigated on the placentae obtained after birth by real time PCR (RT-PCR) analysis. Pre-natal-post-natal, systolic-diastolic blood pressure values, proteinuria and renal function indicators as BUN and creatinine levels of pre-eclamptic pregnant women were higher than the healthy group. Similarly, 5-HT7 receptor expression determined in healthy placentae increased 8-fold in pre-eclamptic women. This study, for the first time we showed 5-HT7 receptor expression in normal placenta and increased expression in pre-eclamptic placenta.
Anahtar kelimeler
Sürdürülebilir Kalkınma Amaçları
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SKA 16: Barış, Adalet ve Güçlü Kurumlar
Atıf için künye
Demir, E., Halıcı, Z., YILMAZ, M., Çadırcı, E., & Karakus, E. (2016). Evaluation of 5-HT7 receptor expression in the placentae of normal and pre-eclamptic women. CLINICAL AND EXPERIMENTAL HYPERTENSION, 38(2), 189–193. https://doi.org/10.3109/10641963.2015.1081215
BibTeX
@article{demir2016-231958,
author = {Demir, Emine and Halıcı, Zekai and YILMAZ, Mehmet and Çadırcı, Elif and Karakus, Emre},
title = {Evaluation of 5-HT7 receptor expression in the placentae of normal and pre-eclamptic women},
journal = {CLINICAL AND EXPERIMENTAL HYPERTENSION},
year = {2016},
volume = {38},
number = {2},
pages = {189--193},
issn = {1064-1963},
doi = {10.3109/10641963.2015.1081215},
url = {https://akademik.atauni.edu.tr/yayinlar/231958-evaluation-of-5-ht7-receptor-expression-in-the-placentae-of-normal-and-pre}
}