A novel approach to contrast-induced nephrotoxicity: the melatonergic agent agomelatine
Özet
Objective: To study the potential nephroprotective role of agomelatine in rat renal tissue in cases of contrast-induced nephrotoxicity (CIN). The drug's action on the antioxidant system and proinflammatory cytokines, superoxide dismutase (SOD) activity, levels of glutathione (GSH) and malondialdehyde (MDA) and the gene expression of interleukin-6 (IL-6), tumour necrosis factor (TNF)-alpha and nuclear factor kappa B (NF-kappa B) was measured. Tubular necrosis and hyaline and haemorrhagic casts were also histopathologically evaluated.
Atıf için künye
Karaman, A., DİYARBAKIR, B., Durur-Subasi, I., KÖSE, D., Ozbek-Bilgin, A., TOPÇU, A., Gundogdu, C., Durur-Karakaya, A., Bayraktutan, Z., & Alper, F. (2016). A novel approach to contrast-induced nephrotoxicity: the melatonergic agent agomelatine. BRITISH JOURNAL OF RADIOLOGY, 89(1061). https://doi.org/10.1259/bjr.20150716
BibTeX
@article{karaman2016-230574,
author = {Karaman, Adem and DİYARBAKIR, Busra and Durur-Subasi, Irmak and KÖSE, Duygu and Ozbek-Bilgin, Asli and TOPÇU, Atilla and Gundogdu, Cemal and Durur-Karakaya, Afak and Bayraktutan, Zafer and Alper, Fatih},
title = {A novel approach to contrast-induced nephrotoxicity: the melatonergic agent agomelatine},
journal = {BRITISH JOURNAL OF RADIOLOGY},
year = {2016},
volume = {89},
number = {1061},
issn = {0007-1285},
doi = {10.1259/bjr.20150716},
url = {https://akademik.atauni.edu.tr/yayinlar/230574-a-novel-approach-to-contrast-induced-nephrotoxicity-the-melatonergic-agent}
}