Characterization of serum N-glycome alterations in seasonal allergic rhinitis using MALDI-TOF-MS: A pilot study
Özet
Seasonal allergic rhinitis (SAR) is an inflammatory process. In this pilot study, matrix assisted laser desorption ionization-mass spectrometry (MALDI-MS)-based analyses were conducted to investigate the effects of SAR on serum N-glycome in a small dataset (n = 10 for both SAR patients and controls). It was detected that two N-glycan compositions (H6N5E2L1 and H6N5E1L2) were down-regulated in SAR patients. Additionally, five tri-antennary N-glycan traits, including both galactosylated and sialylated (A3GS and A3GL) and non-fucosylated (A3F0GE, A3F0GL, A3F0GS) ones, were decreased. Furthermore, three high-antennary and fucosylated N-glycan traits (A3F, A3EF and A4F) were increased in SAR patients compared to controls.
Anahtar kelimeler
Atıf için künye
Yaman, M. E., Avci, I., Atila, N. E., Atila, A., Kayili, H. M., & SALİH, B. (2021). Characterization of serum N-glycome alterations in seasonal allergic rhinitis using MALDI-TOF-MS: A pilot study. JOURNAL OF CARBOHYDRATE CHEMISTRY, 40(6), 269–282. https://doi.org/10.1080/07328303.2021.2009502
BibTeX
@article{yaman2021-23010,
author = {Yaman, Mehmet Emrah and Avci, Izzet and Atila, Nihal Efe and Atila, Alptuğ and Kayili, Haci Mehmet and SALİH, BEKİR},
title = {Characterization of serum N-glycome alterations in seasonal allergic rhinitis using MALDI-TOF-MS: A pilot study},
journal = {JOURNAL OF CARBOHYDRATE CHEMISTRY},
year = {2021},
volume = {40},
number = {6},
pages = {269--282},
issn = {0732-8303},
doi = {10.1080/07328303.2021.2009502},
url = {https://akademik.atauni.edu.tr/yayinlar/23010-characterization-of-serum-n-glycome-alterations-in-seasonal-allergic-rhinitis}
}