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Makale Tam Makale Uluslararası 2016

Study of the boron levels in serum after implantation of different ratios nano-hexagonal boron nitride-hydroxy apatite in rat femurs

Alptuğ Atila, Zekai Halıcı, Elif Çadırcı, Emre Karakus, Saziye Sezin Palabiyik, Nuran Ay, Feray Bakan, Sahin Yilmaz

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS Cilt 58 · ss. 1082–1089 · 01.01.2016
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Özet

Boron and its derivatives are effective in bone recovery and osteointegration. However, increasing the boron levels in body liquids may cause toxicity. The aim of our study is to investigate serum boron levels using ICP-MS after implantation of different ratios of nano-hBN-HA composites in rat femurs. All rats were (n = 126) divided into five experimental groups (n = 24) and one healthy group (6 rats); healthy (Groupl), femoral defect + %100HA (Group2), femoral defect + %2.5hBN + %97.5HA (Group3), femoral defect + %5hBN + %95HA (Group4), femoral defect + %10hBN + %90 HA (Group5), femoral defect + %100hBN (Group6). The femoral defect was created in the distal femur (3 mm drill-bit). Each implant group was divided into four different groups (n = 24) also 6 rats sacrificed for each groups in one week intervals during four weeks. In our results; at 1, 2, 3, and 4 weeks after implantation near bone tissue, serum levels of boron were evaluated using ICP-MS. We demonstrated that neither short-term nor long-term implantation of hBN-HA composite resulted in statistically increased serum boron levels in experimental groups compared to healthy group. In conclusion, this study investigated the implant material produced form hBN-HA for the first time. Our data suggest that hBN is a new promising target for biomaterial and implant bioengineers. (c) 2015 Elsevier B.V. All rights reserved.

Anahtar kelimeler

BONE TITANIUM MECHANICAL-PROPERTIES Serum metal CALCIUM Rat Raman spectroscopy ICP–MS Boron Nano-hexagonal boron nitride Femur DIETARY BORON CHROMIUM SUPPLEMENTATION METABOLISM

Atıf için künye

Atila, A., Halıcı, Z., Çadırcı, E., Karakus, E., Palabiyik, S. S., Ay, N., Bakan, F., & Yilmaz, S. (2016). Study of the boron levels in serum after implantation of different ratios nano-hexagonal boron nitride-hydroxy apatite in rat femurs. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 58, 1082–1089. https://doi.org/10.1016/j.msec.2015.09.041

BibTeX 
@article{atila2016-23003,
  author = {Atila, Alptuğ and Halıcı, Zekai and Çadırcı, Elif and Karakus, Emre and Palabiyik, Saziye Sezin and Ay, Nuran and Bakan, Feray and Yilmaz, Sahin},
  title = {Study of the boron levels in serum after implantation of different ratios nano-hexagonal boron nitride-hydroxy apatite in rat femurs},
  journal = {MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS},
  year = {2016},
  volume = {58},
  pages = {1082--1089},
  issn = {0928-4931},
  doi = {10.1016/j.msec.2015.09.041},
  url = {https://akademik.atauni.edu.tr/yayinlar/23003-study-of-the-boron-levels-in-serum-after-implantation-of-different-ratios-nano}
}