Atatürk Üniversitesi Atatürk Üniversitesi
Ara
Yayınlara dön
Makale Tam Makale Uluslararası 2022 Açık erişimli

Are Antibiotics Sufficient for Treating Bacterial Rhinosinusitis? The Influence of Alpha-Lipoic Acid, a Potent Antioxidant, As an Additional Treatment in Bacterial Rhinosinusitis

Nihal Efe Atila, Zülküf Kaya, Alptuğ Atila, Zekai Halıcı, Yasin Bayir, Busra Sirin, Aysenur Kahramanlar, Elif Çadırcı, Mustafa Ozkaraca, Osman Nuri Keleş, Sevilay Özmen

B-ENT Cilt 18 · Sayı 4 · ss. 216–224 · 01.10.2022
DOI ile aç

Özet

Objective: Alpha-lipoic acid is an antioxidant agent with potential anti-inflammatory properties and is produced from octanoic acid. The aim of this study was to investigate the effects of alpha-lipoic acid on inflammation, oxidative status, tissue integrity in an animal model of experimentally induced acute rhinosinusitis and to compare these effects with the standard treatment, cefalosporin. Methods: Totally 30 healthy Wistar Albino rats were used in the experiment. The animals were randomly divided into 6 groups. An experimental sinusitis model was created Staphylococcus Aureus (SA) in the groups except for the healthy group. Over a 10-day period, groups were treated daily either with 50 mg/kg cefazolin (SA + cefazolin), alpha-lipoic acid 100 mg/kg (SA+ alpha-lipoic acid 100), alpha-lipoic acid 200 mg/kg (SA + alpha-lipoic acid 200), or alpha-lipoic acid 200 mg/kg +cefazolin 50 mg/kg (SA + alpha-lipoic acid 200 + cefazolin). At the end of the test, the animals were euthanized, and the maxillary sinus mucosa was removed. Mucosa samples were examined for superoxide dismutase activity and glutathione, malondialdehyde, tumor necrosis factor-alpha mRNA, and interleukin-1 ss mRNA levels. Results: Histopathological examination showed lesser changes in SA + cefazolin group compared to the control group and inflammation proportionally with alpha-lipoic acid dose in rhinosinusitis-induced groups treated with alpha-lipoic acid. Increased levels of malondialdehyde, tumor necrosis factor-alpha mRNA, and interleukin-1 ss mRNA in rhinosinusitis-induced groups approached the healthy group in SA+ alphalipoic acid 200 + cefazolin group. Decreased superoxide dismutase activity and glutathione level in induced rhinosinusitis groups were close to that of healthy group in SA + alpha-lipoic acid 200 + cefazolin group. Conclusion: The results of the study revealed that using a potent antioxidant and/or anti-inflammatory agent along with an antibacterial agent could be more effective in reducing oxidative stress and cytokine levels in the treatment of bacterial infections like sinusitis.

Anahtar kelimeler

DAMAGE ASSAY antioxidant MECHANISMS alpha lipoic acid MODEL antibiotics bacterial rhinosinusitis PROTECTS

Sürdürülebilir Kalkınma Amaçları

  • SKA 3: Sağlıklı Bireyler

Atıf için künye

Atila, N. E., Kaya, Z., Atila, A., Halıcı, Z., Bayir, Y., Sirin, B., Kahramanlar, A., Çadırcı, E., Ozkaraca, M., Keleş, O. N., & Özmen, S. (2022). Are Antibiotics Sufficient for Treating Bacterial Rhinosinusitis? The Influence of Alpha-Lipoic Acid, a Potent Antioxidant, As an Additional Treatment in Bacterial Rhinosinusitis. B-ENT, 18(4), 216–224. https://doi.org/10.5152/b-ent.2022.21476

BibTeX 
@article{atila2022-22996,
  author = {Atila, Nihal Efe and Kaya, Zülküf and Atila, Alptuğ and Halıcı, Zekai and Bayir, Yasin and Sirin, Busra and Kahramanlar, Aysenur and Çadırcı, Elif and Ozkaraca, Mustafa and Keleş, Osman Nuri and Özmen, Sevilay},
  title = {Are Antibiotics Sufficient for Treating Bacterial Rhinosinusitis? The Influence of Alpha-Lipoic Acid, a Potent Antioxidant, As an Additional Treatment in Bacterial Rhinosinusitis},
  journal = {B-ENT},
  year = {2022},
  volume = {18},
  number = {4},
  pages = {216--224},
  issn = {2684-4907},
  doi = {10.5152/b-ent.2022.21476},
  url = {https://akademik.atauni.edu.tr/yayinlar/22996-are-antibiotics-sufficient-for-treating-bacterial-rhinosinusitis-the-influence}
}