Atatürk Üniversitesi Atatürk Üniversitesi
Ara
Yayınlara dön
Makale Tam Makale Uluslararası 2017

Zinc Sulfate and/or Growth Hormone Administration for the Prevention of Radiation-Induced Dermatitis: a Placebo-Controlled Rat Model Study

Mustafa Kandaz, Mustafa Vecdi Ertekin, Ihsan Karslioglu, Fazli Erdogan, Orhan Sezen, Akcahan Gepdiremen, Cemal Gündoğdu

Biological Trace Element Research Cilt 179 · Sayı 1 · ss. 110–116 · 01.09.2017
DOI ile aç

Özet

Growth hormone (GH) and zinc (Zn) were evaluated for their potential to prevent radiation injury using a rat model of radiation-induced skin injury. Sprague-Dawley rats were divided into five groups: a control group not receiving Zn, GH, or irradiation: a radiation (RT) group receiving a single 30 Gy dose of gamma irradiation to the right hind legs; a radiation + GH group (RT + GH) receiving a single 30 Gy dose of gamma irradiation plus the subcutaneous administration of 0.01 IU kg d(-1) GH; a radiation + Zn group (RT + Zn) receiving a single 30 Gy dose plus 5 mg kg d(-1) Zn po; and a radiation + GH + Zn group (RT + GH + Zn) group receiving a single 30 Gy dose plus subcutaneous 0.01 IU kg d(-1) GH and 5 mg kg d(-1) Zn po. Acute skin reactions were assessed every 3 days by two radiation oncologists grouping. Light microscopic findings were assessed blindly by two pathologists. Groups receiving irradiation were associated with dermatitis as compared to the control group (P < 0.05). The severity of radiodermatitis in the RT + GH, RT + Zn, and RT + GH + Zn groups was significantly lower than that in the RT group (P < 0.05). Furthermore, radiodermatitis was observed earlier in the RT group than in the other treatment groups (P < 0.05). GH and Zn effectively prevented epidermal atrophy, dermal degeneration, and hair follicle atrophy. The highest level of protection against radiation dermatitis was observed in the combination group.

Anahtar kelimeler

DOUBLE-BLIND IN-VITRO THERAPY radiotherapy antioxidant SKIN zinc sulfate Rat growth hormone PREVENTION MUCOSITIS CARCINOMA dermatitis IRRADIATED MICE NECK CANCERS

Atıf için künye

Kandaz, M., Ertekin, M. V., Karslioglu, I., Erdogan, F., Sezen, O., Gepdiremen, A., & Gündoğdu, C. (2017). Zinc Sulfate and/or Growth Hormone Administration for the Prevention of Radiation-Induced Dermatitis: a Placebo-Controlled Rat Model Study. Biological Trace Element Research, 179(1), 110–116. https://doi.org/10.1007/s12011-017-0952-z

BibTeX 
@article{kandaz2017-229697,
  author = {Kandaz, Mustafa and Ertekin, Mustafa Vecdi and Karslioglu, Ihsan and Erdogan, Fazli and Sezen, Orhan and Gepdiremen, Akcahan and Gündoğdu, Cemal},
  title = {Zinc Sulfate and/or Growth Hormone Administration for the Prevention of Radiation-Induced Dermatitis: a Placebo-Controlled Rat Model Study},
  journal = {Biological Trace Element Research},
  year = {2017},
  volume = {179},
  number = {1},
  pages = {110--116},
  issn = {0163-4984},
  doi = {10.1007/s12011-017-0952-z},
  url = {https://akademik.atauni.edu.tr/yayinlar/229697-zinc-sulfate-andor-growth-hormone-administration-for-the-prevention-of-radiation}
}