Risk for cancer development in familial Mediterranean fever and associated predisposing factors: an ambidirectional cohort study from the international AIDA Network registries
Özet
Objective Inflammation has been associated with an increased risk for cancer development, while innate immune system activation could counteract the risk for malignancies. Familial Mediterranean fever (FMF) is a severe systemic inflammatory condition and also represents the archetype of innate immunity deregulation. Therefore, the aim of this study is to investigate the risk for cancer development in FMF.Methods The risk ratio (RR) for malignancies was separately compared between FMF patients and fibromyalgia subjects, Still's disease patients and Beh & ccedil;et's disease patients. Clinical variables associated with cancer development in FMF patients were searched through binary logistic regression.Results 580 FMF patients and 102 fibromyalgia subjects, 1012 Beh & ccedil;et's disease patients and 497 Still's disease patients were enrolled. The RR for the occurrence of malignant neoplasms was 0.26 (95% Confidence Interval [CI.] 0.10-0.73, p=0.006) in patients with FMF compared to fibromyalgia subjects; the RR for the occurrence of malignant cancer was 0.51 (95% CI. 0.23-1.16, p=0.10) in FMF compared to Still's disease and 0.60 (95% CI. 0.29-1.28, p=0.18) in FMF compared to Beh & ccedil;et's disease. At logistic regression, the risk of occurrence of malignant neoplasms in FMF patients was associated with the age at disease onset (beta 1 = 0.039, 95% CI. 0.001-0.071, p=0.02), the age at the diagnosis (beta 1 = 0.048, 95% CI. 0.039-0.085, p=0.006), the age at the enrolment (beta 1 = 0.05, 95% CI. 0.007-0.068, p=0.01), the number of attacks per year (beta 1 = 0.011, 95% CI. 0.001- 0.019, p=0.008), the use of biotechnological agents (beta 1 = 1.77, 95% CI. 0.43-3.19, p=0.009), the use of anti-IL-1 agents (beta 1 = 2.089, 95% CI. 0.7-3.5, p=0.002).Conclusions The risk for cancer is reduced in Caucasic FMF patients; however, when malignant neoplasms occur, this is more frequent in FMF cases suffering from a severe disease phenotype and presenting a colchicine-resistant disease.
Sürdürülebilir Kalkınma Amaçları
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SKA 3: Sağlıklı Bireyler
Atıf için künye
Vitale, A., Caggiano, V., TUFAN, A., Ragab, G., BATU AKAL, E. D., Portincasa, P., Aragona, E., Sota, J., Conti, G., De Paulis, A., Rigante, D., Olivieri, A. N., Şahin, A., La Torre, F., Lopalco, G., Cattalini, M., Maggio, M. C., Insalaco, A., Sfikakis, P. P., … Cantarini, L. (2024). Risk for cancer development in familial Mediterranean fever and associated predisposing factors: an ambidirectional cohort study from the international AIDA Network registries. FRONTIERS IN IMMUNOLOGY, 15. https://doi.org/10.3389/fimmu.2024.1397890
BibTeX
@article{vitale2024-229221,
author = {Vitale, Antonio and Caggiano, Valeria and TUFAN, ABDURRAHMAN and Ragab, Gaafar and BATU AKAL, EZGİ DENİZ and Portincasa, Piero and Aragona, Emma and Sota, Jurgen and Conti, Giovanni and De Paulis, Amato and Rigante, Donato and Olivieri, Alma Nunzia and Şahin, Ali and La Torre, Francesco and Lopalco, Giuseppe and Cattalini, Marco and Maggio, Maria Cristina and Insalaco, Antonella and Sfikakis, Petros P. and Verrecchia, Elena and Yildirim, Derya and Kucuk, Hamit and Kardas, Riza Can and Laymouna, Ahmed Hatem and Ghanema, Mahmoud and Saad, Moustafa Ali and Sener, Seher and Ercan Emreol, Hulya and Ozen, Seza and Jaber, Nour and Khalil, Mohamad and Di Ciaula, Agostino and Gaggiano, Carla and Malizia, Giuseppe and Affronti, Andrea and Patroniti, Serena and Romeo, Meri and Sbalchiero, Jessica and Della Casa, Francesca and Mormile, Ilaria and Silvaroli, Sara and Gicchino, Maria Francesca and Celik, Nese cabuk and Tarsia, Maria and Karamanakos, Anastasios and Hernandez-Rodriguez, Jose and Parronchi, Paola and Opris-Belinski, Daniela and Barone, Patrizia and Recke, Andreas and Costi, Stefania and Sfriso, Paolo and Giardini, Henrique A. Mayrink and Gentileschi, Stefano and Wiesik-Szewczyk, Ewa and Vasi, Ibrahim and Loconte, Roberta and Jahnz-Rozyk, Karina and Martin-Nares, Eduardo and Torres-Ruiz, Jiram and Cauli, Alberto and Conforti, Alessandro and Emmi, Giacomo and Li Gobbi, Francesca and Biasi, Giovanni Rosario and Terribili, Riccardo and Ruscitti, Piero and Del Giudice, Emanuela and Tharwat, Samar and Brucato, Antonio Luca and Ogunjimi, Benson and Hinojosa-Azaola, Andrea and Balistreri, Alberto and Fabiani, Claudia and Frediani, Bruno and Cantarini, Luca},
title = {Risk for cancer development in familial Mediterranean fever and associated predisposing factors: an ambidirectional cohort study from the international AIDA Network registries},
journal = {FRONTIERS IN IMMUNOLOGY},
year = {2024},
volume = {15},
issn = {1664-3224},
doi = {10.3389/fimmu.2024.1397890},
url = {https://akademik.atauni.edu.tr/yayinlar/229221-risk-for-cancer-development-in-familial-mediterranean-fever-and-associated}
}