Impact of HLA-B51 on Uveitis and Retinal Vasculitis: Data from the AIDA International Network Registries on Ocular Inflammatory Disorders
Özet
PurposeThe clinical relevance of human leukocyte antigen (HLA) subtypes such as HLA-B51 on Beh & ccedil;et's disease (BD)-related uveitis and non-infectious uveitis (NIU) unrelated to BD remains largely unknown.MethodsData were prospectively collected from the International AIDA Network Registry for BD and for NIU. We assessed differences between groups (NIU unrelated to BD and positive for HLA-B51, BD-related uveitis positive for HLA-B51 and BD-related uveitis negative for HLA-B51) in terms of long-term ocular complications, visual acuity (VA) measured by best corrected visual acuity (BCVA), anatomical pattern, occurrence of retinal vasculitis (RV) and macular edema over time.ResultsRecords of 213 patients (341 eyes) were analyzed. No differences in complications were observed (p = 0.465). With regard to VA, a significant difference was detected in median BCVA (p = 0.046), which was not maintained after Bonferroni correction (p = 0.060). RV was significantly more prevalent in NIU-affected patients who tested positive for HLA-B51, irrespective of the systemic diagnosis of BD (p = 0.025). No differences emerged in the occurrence of macular edema (p = 0.99).ConclusionsPatients with NIU testing positive for HLA-B51 exhibit an increased likelihood of RV throughout disease course, irrespective of a systemic diagnosis of BD. The rate of complications as well as VA are comparable between NIU cases unrelated to BD testing positive for HLA-B51 and uveitis associated with BD. Therefore, it is advisable to perform the HLA-B typing in patients with NIU or retinal vasculitis, even in the absence of typical BD features.
Anahtar kelimeler
Sürdürülebilir Kalkınma Amaçları
-
SKA 3: Sağlıklı Bireyler
Atıf için künye
Sota, J., Guerriero, S., Lopalco, G., TUFAN, A., Ragab, G., Almaglouth, I., Govoni, M., Sfikakis, P. P., Frassi, M., Vitale, A., Kardas, R. C., Triaggianese, P., Chimenti, M. S., Aboabat, A. A., Piga, M., Monti, S., Sebastiani, G. D., Yildirim, D., Conforti, A., … Fabiani, C. (2025). Impact of HLA-B51 on Uveitis and Retinal Vasculitis: Data from the AIDA International Network Registries on Ocular Inflammatory Disorders. OCULAR IMMUNOLOGY AND INFLAMMATION, 33(1), 48–55. https://doi.org/10.1080/09273948.2024.2346815
BibTeX
@article{sota2025-229218,
author = {Sota, Jurgen and Guerriero, Silvana and Lopalco, Giuseppe and TUFAN, ABDURRAHMAN and Ragab, Gaafar and Almaglouth, Ibrahim and Govoni, Marcello and Sfikakis, Petros P. and Frassi, Micol and Vitale, Antonio and Kardas, Riza Can and Triaggianese, Paola and Chimenti, Maria Sole and Aboabat, Aos A. and Piga, Matteo and Monti, Sara and Sebastiani, Gian Domenico and Yildirim, Derya and Conforti, Alessandro and Gentileschi, Stefano and Dammacco, Rosanna and Hinojosa-Azaola, Andrea and Kawakami-Campos, Perla Ayumi and Ruffilli, Francesca and Torres-Ruiz, Jiram and Thabet, Maissa and Atig, Amira and Ruscitti, Piero and Cataldi, Giulia and Viapiana, Ombretta and Hatemi, Guelen and Karakoc, Alican and Costi, Stefania and Iagnocco, Annamaria and Crisafulli, Francesca and Fragoulis, George and Del Giudice, Emanuela and Hegazy, Mohamed Tharwat and Paroli, Maria Pia and Şahin, Ali and Morrone, Maria and Iannone, Florenzo and Opris-Belinski, Daniela and Asfina, Kazi Nur and Barone, Patrizia and Gaggiano, Carla and Kucuk, Hamit and Gicchino, Maria Francesca and Carubbi, Francesco and Caggiano, Valeria and Laskari, Katerina and Tharwat, Samar and Direskeneli, Haner and Alibaz-Oner, Fatma and Sevik, Gizem and Maier, Armin and Laymouna, Ahmed Hatem and Emmi, Giacomo and Akkoc, Nurullah and Tarsia, Maria and Sbalchiero, Jessica and Conti, Giovanni and Spinella, Rosaria and La Torre, Francesco and Tombetti, Enrico and Amin, Rana Hussein and Mauro, Angela and Karamanakos, Anastasios and Carreno, Ester and Fonollosa, Alex and Cattalini, Marco and Breda, Luciana and de-la-Torre, Alejandra and Wiesik-Szewczyk, Ewa and Cifuentes-Gonzalez, Carlos and Ozen, Seza and Mazzei, Maria Antonietta and Tosi, Gian Marco and Frediani, Bruno and Balistreri, Alberto and Batu, Ezgi Deniz and Gupta, Vishali and Cantarini, Luca and Fabiani, Claudia},
title = {Impact of HLA-B51 on Uveitis and Retinal Vasculitis: Data from the AIDA International Network Registries on Ocular Inflammatory Disorders},
journal = {OCULAR IMMUNOLOGY AND INFLAMMATION},
year = {2025},
volume = {33},
number = {1},
pages = {48--55},
issn = {0927-3948},
doi = {10.1080/09273948.2024.2346815},
url = {https://akademik.atauni.edu.tr/yayinlar/229218-impact-of-hla-b51-on-uveitis-and-retinal-vasculitis-data-from-the-aida}
}