Impact of Neutrophil-to-Lymphocyte Ratio on Stroke Severity and Clinical Outcome in Anterior Circulation Large Vessel Occlusion Stroke
Özet
Background: The prognostic value of the neutrophil–lymphocyte ratio (NLR) in ischemic stroke remains debated due to cohort variability and treatment heterogeneity across studies. This study evaluates the relationship between admission NLR, stroke severity and 90-day outcomes in patients with anterior circulation large vessel occlusion (LVO) undergoing early, successful revascularization. Methods: A retrospective multicenter study was conducted with 1082 patients treated with mechanical thrombectomy for acute ischemic stroke. The relationship between admission NLR, baseline National Institutes of Health Stroke Scale (NIHSS), 24 h NIHSS and 90-day modified Rankin Scale (mRS) outcomes was analyzed using logistic regression. Results: Admission NLR correlated weakly but significantly with both baseline (p = 0.018) and 24 h (p = 0.005) NIHSS scores, reflecting stroke severity. However, multivariate analysis showed that higher 24 h NIHSS scores (OR 0.831, p = 0.000) and prolonged puncture-to-recanalization times (OR 0.981, p = 0.000) were independent predictors of poor 90-day outcomes, whereas NLR was not (p = 0.557). Conclusions: Admission NLR is associated with stroke severity but does not independently predict clinical outcomes at 90 days in patients achieving early and successful revascularization. These findings underscore the critical role of inflammation in the acute phase of stroke but suggest that its prognostic value for long-term outcomes is limited in this context.
Anahtar kelimeler
Atıf için künye
Memiş, Z., Gürkaş, E., Özdemir, A. Ö., Acar, B. A., Ögün, M. N., Aytaç, E., Akpınar, Ç. K., Akıl, E., Çabalar, M., Özkul, A., Görgülü, Ü., Bayındır, H., Mehdiyev, Z., Delibaş Katı, Ş., Baydemir, R., Yabalak, A., Önalan, A., Acar, T., Aykaç, Ö., … Asil, T. (2024). Impact of Neutrophil-to-Lymphocyte Ratio on Stroke Severity and Clinical Outcome in Anterior Circulation Large Vessel Occlusion Stroke. Diagnostics, 14(24). https://doi.org/10.3390/diagnostics14242880
BibTeX
@article{memis2024-229060,
author = {Memiş, Zülfikar and Gürkaş, Erdem and Özdemir, Atilla Özcan and Acar, Bilgehan Atılgan and Ögün, Muhammed Nur and Aytaç, Emrah and Akpınar, Çetin Kürşad and Akıl, Eşref and Çabalar, Murat and Özkul, Ayça and Görgülü, Ümit and Bayındır, Hasan and Mehdiyev, Zaur and Delibaş Katı, Şennur and Baydemir, Recep and Yabalak, Ahmet and Önalan, Ayşenur and Acar, Türkan and Aykaç, Özlem and Uysal Kocabaş, Zehra and Yıldırım, Serhan and Doğan, Hasan and Arı, Mehmet Semih and Çetiner, Mustafa and Balgetir, Ferhat and Eren, Fettah and Eren, Alper and KIZILDAĞ, Nazım and Cenikli, Utku and Şişman Bayar, Aysel Büşra and Temel, Ebru and Akbaş, Alihan Abdullah and Saygın Uysal, Emine and Gültekin, Hamza and Durmaz, Cebrail and Boncuk Ulaş, Sena and Asil, Talip},
title = {Impact of Neutrophil-to-Lymphocyte Ratio on Stroke Severity and Clinical Outcome in Anterior Circulation Large Vessel Occlusion Stroke},
journal = {Diagnostics},
year = {2024},
volume = {14},
number = {24},
issn = {2075-4418},
doi = {10.3390/diagnostics14242880},
url = {https://akademik.atauni.edu.tr/yayinlar/229060-impact-of-neutrophil-to-lymphocyte-ratio-on-stroke-severity-and-clinical-outcome}
}