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Makale Tam Makale Uluslararası 2021

Significance of MPV, RDW and PDW with the Severity and Mortality of COVID-19 and Effects of Acetylsalicylic Acid Use

Faruk Aydinyilmaz, Emrah Aksakal, Hilal Erken Pamukcu, Selim Aydemir, Remziye Dogan, İbrahim Sarac, Sidar Şiyar Aydin, Kamuran Kalkan, Oktay Gülcü, Ibrahim Halil Tanboga

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS 01.10.2021
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Özet

We aimed to investigate association between mean platelet volume (MVP), platelet distribution width (PDW) and red cell distribution width (RDW) and mortality in patients with COVID-19 and find out in which patients the use of acetylsalicylic acid (ASA) affects the prognosis due to the effect of MPV on thromboxan A2. A total of 5142 patients were divided into those followed in the intensive care unit (ICU) and those followed in the ward. Patient medical records were examined retrospectively. ROC analysis showed that the area under curve (AUC) values were 0.714, 0.750, 0.843 for MPV, RDW and D-Dimer, the cutoff value was 10.45fl, 43.65fl, 500.2 ng/mL respectively. (all P < .001). Survival analysis showed that patients with MPV >10.45 f/l and D-Dimer >500.2 ng/mL, treatment with ASA had lower in-hospital and 180-day mortality than patients without ASA in ICU patients (HR = 0.773; 95% CI = 0.595-0.992; P = .048, HR = 0.763; 95% CI = 0.590-0.987; P = .036). Administration of low-dose ASA in addition to anti-coagulant according to MPV and D-dimer levels reduces mortality.

Anahtar kelimeler

COVID-19 red cell distribution width Mean Platelet Volume Platelet distribution width

Sürdürülebilir Kalkınma Amaçları

  • SKA 3: Sağlıklı Bireyler

Atıf için künye

Aydinyilmaz, F., Aksakal, E., Pamukcu, H. E., Aydemir, S., Dogan, R., Sarac, İ., Aydin, S. Ş., Kalkan, K., Gülcü, O., & Tanboga, I. H. (2021). Significance of MPV, RDW and PDW with the Severity and Mortality of COVID-19 and Effects of Acetylsalicylic Acid Use. CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS. https://doi.org/10.1177/10760296211048808

BibTeX 
@article{aydinyilmaz2021-228957,
  author = {Aydinyilmaz, Faruk and Aksakal, Emrah and Pamukcu, Hilal Erken and Aydemir, Selim and Dogan, Remziye and Sarac, İbrahim and Aydin, Sidar Şiyar and Kalkan, Kamuran and Gülcü, Oktay and Tanboga, Ibrahim Halil},
  title = {Significance of MPV, RDW and PDW with the Severity and Mortality of COVID-19 and Effects of Acetylsalicylic Acid Use},
  journal = {CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS},
  year = {2021},
  issn = {1076-0296},
  doi = {10.1177/10760296211048808},
  url = {https://akademik.atauni.edu.tr/yayinlar/228957-significance-of-mpv-rdw-and-pdw-with-the-severity-and-mortality-of-covid-19-and}
}