Plasma values of oxidants and antioxidants in acute brain hemorrhage - Role of free radicals in the development of brain injury

Aygcul, R; Demircan, B; Erdem, Fuat; Ulvi, H; Yildirim, A; Demirbas, F

Makale Tam Makale Uluslararası 2005

Plasma values of oxidants and antioxidants in acute brain hemorrhage - Role of free radicals in the development of brain injury

R Aygcul, B Demircan, Fuat Erdem, H Ulvi, A Yildirim, F Demirbas

Biological Trace Element Research Cilt 108 · ss. 43–52 · 01.12.2005

Özet

The levels of oxidants xanthine oxidase (XO), nitric oxide (NO), and malondialdehyde (MDA) and of the antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and glutathione reductase (GRID) were determined in plasma within 24 h after onset of hemorrhagic stroke in 17 patients (9 men and 8 women, aged 60.7 +/- 11.5 yr) and in 20 healthy controls (12 men and 8 women, aged 62.5 +/- 8.3 yr). Compared to controls, the plasma SOD and total superoxide scavenger activities (TSSA) were significantly lower and the NO levels were significantly higher among the stroke patients. XO showed a slight, nonsignificant increase in the patients, but the levels of MDA, NSSA, GRD, and GSH-Px did not show any significant differences between the two groups. The hemorrhage volume was negatively correlated with the initial score of the Glasgow Coma Scale and a positive correlation with lethal outcome, but it did not correlate significantly with any of the measured parameters. The results suggest that free radicals might play a role in the development of brain injury following brain hemorrhage.

Anahtar kelimeler

NITRIC-OXIDE reactive oxygen species LIPID-PEROXIDATION malondialdehyde ANTIOXIDANT ENZYMES Xanthine oxidase brain hemorrhage oxidative brain injury

Sürdürülebilir Kalkınma Amaçları

SKA 16: Barış, Adalet ve Güçlü Kurumlar

Atıf için künye

Aygcul, R., Demircan, B., Erdem, F., Ulvi, H., Yildirim, A., & Demirbas, F. (2005). Plasma values of oxidants and antioxidants in acute brain hemorrhage - Role of free radicals in the development of brain injury. Biological Trace Element Research, 108, 43–52.

BibTeX

@article{aygcul2005-228511,
  author = {Aygcul, R and Demircan, B and Erdem, Fuat and Ulvi, H and Yildirim, A and Demirbas, F},
  title = {Plasma values of oxidants and antioxidants in acute brain hemorrhage - Role of free radicals in the development of brain injury},
  journal = {Biological Trace Element Research},
  year = {2005},
  volume = {108},
  pages = {43--52},
  issn = {0163-4984},
  url = {https://akademik.atauni.edu.tr/yayinlar/228511-plasma-values-of-oxidants-and-antioxidants-in-acute-brain-hemorrhage-role-of}
}