Efficacy and Safety of Trastuzumab Emtansine in Her2 Positive Metastatic Breast Cancer: Real-World Experience
Özet
Aim The aim of this study is to evaluate the efficacy and toxicity of trastuzumab emtansine (T-DM1) in cases with metastatic breast cancer (mBC) in different lines of treatment. Method Retrospective analysis of T-DM1 results of human epidermal growth factor receptor 2 (Her2) positive 414 cases with mBC from 31 centers in Turkey. Findings Except 2, all of the cases were female with a median age of 47. T-DM1 had been used as second-line therapy in 37.7% of the cases and the median number of T-DM1 cycles was 9. Progression-free survival (PFS) and overall survival (OS) times were different according to the line of treatment. The median OS was found as 43, 41, 46, 23 and 17 months for 1st, 2nd, 3rd, 4th and 5th line, respectively (p = 0.032) while the median PFS was found as 37, 12, 8, 8 and 8 months, respectively (p = 0.0001). Treatment was well tolerated by the patients. The most common grade 3-4 adverse effects were thrombocytopenia (2.7%) and increased serum gamma-glutamyl transferase (2%). Discussion The best of our knowledge this is the largest real-life experience about the safety and efficacy of T-DM1 use in cases with mBC after progression of Her2 targeted treatment. This study suggests and supports that T-DM1 is more effective in earlier lines of treatment and is a reliable option for mBC.
Sürdürülebilir Kalkınma Amaçları
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SKA 3: Sağlıklı Bireyler
Atıf için künye
Bahceci, A., PAYDAŞ, S., Ak, N., Ferhatoglu, F., Saip, P. M., SEYDAOĞLU, G., Bilici, M., ŞİMŞEK, M., TEKİN, S. B., Calikusu, Z., Yavuz, S., ŞAHİN, A. B., ÇUBUKÇU, E., EVRENSEL, T., Degirmencioglu, S., Demiray, A. G., Yumuk, P. F., Alan, O., Cikman, D. I., … Yildirim, N. (2021). Efficacy and Safety of Trastuzumab Emtansine in Her2 Positive Metastatic Breast Cancer: Real-World Experience. CANCER INVESTIGATION, 39, 473–481. https://doi.org/10.1080/07357907.2021.1933011
BibTeX
@article{bahceci2021-228413,
author = {Bahceci, Aykut and PAYDAŞ, SEMRA and Ak, Naziye and Ferhatoglu, Ferhat and Saip, Pinar Mualla and SEYDAOĞLU, GÜLŞAH and Bilici, Mehmet and ŞİMŞEK, Melih and TEKİN, Salim Başol and Calikusu, Zuleyha and Yavuz, Sinan and ŞAHİN, AHMET BİLGEHAN and ÇUBUKÇU, ERDEM and EVRENSEL, TÜRKKAN and Degirmencioglu, Serkan and Demiray, Atike Gokcen and Yumuk, Perran Fulden and Alan, Ozkan and Cikman, Duygu Ilke and Demirelli, Fuat Hulusi and Kostek, Osman and Gokyer, Ali and Dogan, Mutlu and Bal, Oznur and ÇAKAR, BURCU and GÖKMEN, ERHAN and Yamac, Deniz and Korkmaz, Taner and Aliyev, Altay and KESKİN, ÖZGE and Urvay, Semiha and BÜYÜKŞİMŞEK, MAHMUT and Karadeniz, Cemile and Yildiz, Birol and Cinkir, Havva Yesil and Demir, Hacer and Beypinar, Ismail and Karacin, Cengiz and Eser, Kadir and Baykara, Meltem and KILIÇKAP, SAADETTİN and Okutur, Kerem and Bulut, Gulcan and Alkan, Ali and Arpaci, Erkan and Pilanci, Kezban Nur and Demir, Atakan and Isik, Deniz and Yildirim, Nilgun},
title = {Efficacy and Safety of Trastuzumab Emtansine in Her2 Positive Metastatic Breast Cancer: Real-World Experience},
journal = {CANCER INVESTIGATION},
year = {2021},
volume = {39},
pages = {473--481},
issn = {0735-7907},
doi = {10.1080/07357907.2021.1933011},
url = {https://akademik.atauni.edu.tr/yayinlar/228413-efficacy-and-safety-of-trastuzumab-emtansine-in-her2-positive-metastatic-breast}
}