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Biological Subtypes and Distant Relapse Pattern in Breast Cancer Patients After Curative Surgery (Study of Anatolian Society of Medical Oncology)

Muhammet A. Kaplan, Ulku Y. Arslan, Abdurrahman Isikdogan, FAYSAL DANE, Berna Oksuzoglu, MEVLÜDE İNANÇ, Tulay Akman, MEHMET KÜÇÜKÖNER, Havva Y. Cinkir, Rashad Rzazade, METİN ÖZKAN, Ugur Yilmaz, Ibrahim V. Bayoglu, Yusuf Gunaydin, Meltem Baykara, Dogan Yazilitas, Erdem Cubukcu, Ali Suner, Ugur Ersoy, Mehmet Bilici, Ozan Yazici, Kerim Cayir, Umut Demirci, MÜKREMİN UYSAL

BREAST CARE Cilt 11 · Sayı 4 · ss. 248–252 · 01.01.2016
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Özet

Purpose: The aim of the study was to investigate the association between the molecular subtypes and patterns of relapse in breast cancer patients who had undergone curative surgery. Methods: We retrospectively evaluated 1,350 breast cancer patients with relapses after curative surgery between 1998 and 2012 from referral centers in Turkey. Patients were divided into 4 biological subtypes according to immunohistochennistry and grade: triple negative, HER2 overexpressing, luminal A and luminal B. Results: The percentages of patients with luminal A, lumina! B, HER2-overexpressing, and triple-negative breast cancer were 32.9% (n = 444), 34.9% (n = 471), 12.0% (n = 162), and 20.2% (n = 273), respectively. The distribution of metastases differed among the subgroups: bone (66.2% and 53.9% in lumina! A and B vs. 38.9% in HER2-overexpressing and 45.1% in triple negative, p < 0.001), liver (40.1% in HER2-overexpressing vs. 24.5% in lumina! A, 33.5% in luminal B, and 27.5% in triple negative, p < 0.001), lung (41.4% in triple negative and 35.2% in HER2-overexpressing vs. 30.2% and 30.6% in luminal A and B, p = 0.008) and brain (25.3% in HER2overexpressing and 23.1% in triple negative vs. 10.1% and 15.1% in lumina! A and B, p < 0.001). Conclusions: Organ -specific metastasis may depend on the molecular subtype of breast cancer. Tailored strategies against distant metastasis concerning the molecular subtypes in breast cancer should be considered. (C) 2016 S. Karger GmbH, Freiburg.

Anahtar kelimeler

Breast cancer Relapse pattern Molecular subtype

Sürdürülebilir Kalkınma Amaçları

  • SKA 3: Sağlıklı Bireyler

Atıf için künye

Kaplan, M. A., Arslan, U. Y., Isikdogan, A., DANE, F., Oksuzoglu, B., İNANÇ, M., Akman, T., KÜÇÜKÖNER, M., Cinkir, H. Y., Rzazade, R., ÖZKAN, M., Yilmaz, U., Bayoglu, I. V., Gunaydin, Y., Baykara, M., Yazilitas, D., Cubukcu, E., Suner, A., Ersoy, U., … UYSAL, M. (2016). Biological Subtypes and Distant Relapse Pattern in Breast Cancer Patients After Curative Surgery (Study of Anatolian Society of Medical Oncology). BREAST CARE, 11(4), 248–252. https://doi.org/10.1159/000448186

BibTeX 
@article{kaplan2016-228381,
  author = {Kaplan, Muhammet A. and Arslan, Ulku Y. and Isikdogan, Abdurrahman and DANE, FAYSAL and Oksuzoglu, Berna and İNANÇ, MEVLÜDE and Akman, Tulay and KÜÇÜKÖNER, MEHMET and Cinkir, Havva Y. and Rzazade, Rashad and ÖZKAN, METİN and Yilmaz, Ugur and Bayoglu, Ibrahim V. and Gunaydin, Yusuf and Baykara, Meltem and Yazilitas, Dogan and Cubukcu, Erdem and Suner, Ali and Ersoy, Ugur and Bilici, Mehmet and Yazici, Ozan and Cayir, Kerim and Demirci, Umut and UYSAL, MÜKREMİN},
  title = {Biological Subtypes and Distant Relapse Pattern in Breast Cancer Patients After Curative Surgery (Study of Anatolian Society of Medical Oncology)},
  journal = {BREAST CARE},
  year = {2016},
  volume = {11},
  number = {4},
  pages = {248--252},
  issn = {1661-3791},
  doi = {10.1159/000448186},
  url = {https://akademik.atauni.edu.tr/yayinlar/228381-biological-subtypes-and-distant-relapse-pattern-in-breast-cancer-patients-after}
}