Temporal trends and regional variations in hepatocellular carcinoma etiology: a multinational study across Asia
Özet
Background: Hepatocellular carcinoma (HCC) remains a major health burden in Asia. Advances in antiviral therapies are reshaping the etiological landscape of HCC. This study evaluated temporal shifts in HCC etiology across Asian countries and their clinical implications. Methods: This multinational study analyzed 6,261 newly diagnosed HCC patients registered in the APASL Hepatology/Oncology Consortium (A-HOC) from 19 centers across seven Asian countries and regions between 2013 and 2023. Data on demographics, tumor characteristics, etiology, and treatment patterns were collected. Etiologies included hepatitis B virus (HBV), hepatitis C virus (HCV), alcoholic liver disease (ALD), metabolic dysfunction-associated fatty liver disease (MAFLD), MAFLD plus excess alcoholic intake (MAFLD + eAL), autoimmune liver disease, cryptogenic, and others. Temporal trends and regional variations were assessed. Results: In many countries, HBV remained predominant (43.3%–69.5%) and relatively stable throughout the period, while HCV showed only modest reductions. In Japan, HCV was the leading cause of HCC (33.1%), with a significant decline over time, accompanied by a rise in MAFLD-related HCC. ALD-related HCC increased in South Korea, and MAFLD-related HCC rose in Turkey. Tumor size and stage at diagnosis varied by etiology and region, affecting treatment strategies. Early-stage diagnosis was more frequent in Japan and Taiwan, whereas advanced-stage HCC was common in China and Indonesia. Conclusions: Distinct regional patterns and temporal changes in HCC etiology across Asia highlight the need for tailored prevention and surveillance measures. The growing burden of MAFLD-related HCC emphasizes its emerging role in liver cancer development, particularly in regions with declining viral hepatitis.
Anahtar kelimeler
Atıf için künye
Takeuchi, Y., Tateishi, R., Obi, S., Otsuka, M., Mochizuki, H., Jazag, A., Yokosuka, O., Ogasawara, S., Kanogawa, N., Gonchig, E., Matsushita, Y., Kekilli, M., Bilican, G., Kim, Y. J., Hur, M. H., Yu, M., Huang, C., Morishita, A., Oura, K., … Omata, M. (2026). Temporal trends and regional variations in hepatocellular carcinoma etiology: a multinational study across Asia. Hepatology International, 20(2), 373–383. https://doi.org/10.1007/s12072-026-11037-z
BibTeX
@article{takeuchi2026-228241,
author = {Takeuchi, Yasuto and Tateishi, Ryosuke and Obi, Shuntaro and Otsuka, Motoyuki and Mochizuki, Hitoshi and Jazag, Amarsanaa and Yokosuka, Osamu and Ogasawara, Sadahisa and Kanogawa, Naoya and Gonchig, Erdenebayar and Matsushita, Yuki and Kekilli, Murat and Bilican, Gulden and Kim, Yoon Jun and Hur, Moon Haeng and Yu, Ming-Lung and Huang, Chung-Feng and Morishita, Asahiro and Oura, Kyoko and Komori, Atsumasa and Motoyoshi, Yasuhide and Siregar, Lianda and Loho, Imelda and Yang, Ming and Okabe, Shuichirou and Ueno, Yoshiyuki and Katsumi, Tomohiro and Sato, Takahisa and Kogure, Hirofumi and Masuzaki, Ryota and Lesmana, Cosmas Rinaldi and Nababan, S.H.H. and Nimanong, Supot and Huang, Yi-Hsiang and Nagamatsu, Hiroaki and Yoshida, Hideo and Uchino, Koji and Hasan, Irsan and Kitiyakara, Taya and Akamatsu, Masatoshi and Okamoto, Makoto and Kondo, Mayuko and Moriyama, Makoto and Sukeepaisarnjareon, Wattana and Tangkijvanich, Pisit and Thanapirom, Kessarin and Yalcin, Kendal and Kızıl, Hayriye Dilan and Adali, Gupse and Akdogan, Meral and Gokce, Dilara Turan and Balaban, Yasemin and Gokcan, Hale and Coşar, Arif Mansur and Harputluoglu, Murat and Bahçecioğlu, İbrahim Halil and Atasoy, Alp and Kockar, Muhammet Cem and Dursun, Hakan and Eminler, Ahmet Tarik and Sollano, Jose and Su, Dong Jin and Piratvisuth, Teerha and Kao, Jia-Horng and Crawford, Darrell and Hou, Jinlin and Sharma, Barjesh Chander and Payawal, Diana Alcantara and Gani, Rino Alvani and Tanwandee, Tawesak and Yang, Jin Mo and Lin, Han-Chieh and Shiina, Shuichiro and Jia, Ji-Dong and Lau, George and Örmeci, Necati and Dokmeci, A. Kadir and Wei, Lai and Sarin, Shiv Kumar and Omata, Masao},
title = {Temporal trends and regional variations in hepatocellular carcinoma etiology: a multinational study across Asia},
journal = {Hepatology International},
year = {2026},
volume = {20},
number = {2},
pages = {373--383},
issn = {1936-0533},
doi = {10.1007/s12072-026-11037-z},
url = {https://akademik.atauni.edu.tr/yayinlar/228241-temporal-trends-and-regional-variations-in-hepatocellular-carcinoma-etiology-a}
}