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Makale Tam Makale Uluslararası 2008

Investigation of free radical scavenging enzyme activities and lipid peroxidation in liver tissue of zinc deficient rats

Hasan Kaya, Seyithan Taysi, Abdullah Kaya, Abdullah Boyuk, Hakan Dursun, Yahya Islamoglu, Didem Tastekin, Oztekin Cikman

ASIAN JOURNAL OF CHEMISTRY Cilt 20 · Sayı 2 · ss. 1068–1074 · 01.02.2008

Özet

The aim of this study was to evaluate the lipid peroxidation and free radical scavenging enzyme activities in liver tissue of zinc (Zn)-deficient rats and investigate relationship among these parameters in either group. 16 Male rats with a weight of 35-40 g were used for the experiment. The rats were divided into control (n = 8) and Zn-deficient groups. After 4 weeks of feeding, the rats were killed by cervical dislocation and liver tissues were removed. Biochemical measurements in liver tissue were carried out using a spectrophotometer. Catalase, glutathione peroxidase, glutathione reductase, glutathione S transferase activities, total (enzymatic plus non-enzymatic) superoxide scavenger activity, superoxide dismutase, non-enzymatic superoxide scavenger activity, superoxide dismutase activities and Zn level in the Zn-deficient group were significantly lower than those of the control group, whereas malondialdehyde level was significantly higher than those of the control group. Slightly increased non-enzymatic superoxide scavenger activity was not significantly different from the controls. The results obtained in this study demonstrate that Zn-deficiency causes a decrease in antioxidant defence system and an increase in oxidative stress in liver tissue in rats.

Anahtar kelimeler

ZINC DISEASE oxidative stress Trace elements Free radicals LIPID-PEROXIDATION malondialdehyde antioxidant ANTIOXIDANT ENZYMES Glutathione SKELETAL-MUSCLE trace element OXYGEN RADICALS SERUM OXIDANT/ANTIOXIDANT STATUS SUPEROXIDE-DISMUTASE ACTIVITY DIETARY ZINC

Atıf için künye

Kaya, H., Taysi, S., Kaya, A., Boyuk, A., Dursun, H., Islamoglu, Y., Tastekin, D., & Cikman, O. (2008). Investigation of free radical scavenging enzyme activities and lipid peroxidation in liver tissue of zinc deficient rats. ASIAN JOURNAL OF CHEMISTRY, 20(2), 1068–1074.

BibTeX 
@article{kaya2008-228231,
  author = {Kaya, Hasan and Taysi, Seyithan and Kaya, Abdullah and Boyuk, Abdullah and Dursun, Hakan and Islamoglu, Yahya and Tastekin, Didem and Cikman, Oztekin},
  title = {Investigation of free radical scavenging enzyme activities and lipid peroxidation in liver tissue of zinc deficient rats},
  journal = {ASIAN JOURNAL OF CHEMISTRY},
  year = {2008},
  volume = {20},
  number = {2},
  pages = {1068--1074},
  issn = {0970-7077},
  url = {https://akademik.atauni.edu.tr/yayinlar/228231-investigation-of-free-radical-scavenging-enzyme-activities-and-lipid}
}