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Makale Tam Makale Uluslararası 2010

Antioxidative status and lipid peroxidation in kidney tissue of rats fed with vitamin B-6-deficient diet

Mustafa Keles, BEHÇET AL, Kenan Gumustekin, Berna Demircan, İsa ÖZBEY, Mehmet Akyuz, ADNAN YILMAZ, Elif Demir, Abdullah Uyanık, Tevfik ZİYPAK, SEYİTHAN TAYSI

Renal failure Cilt 32 · Sayı 5 · ss. 618–622 · 01.01.2010
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Özet

Introduction: The aim of this study was to evaluate lipid peroxidation (LP) and free radical scavenging enzyme activities in kidney tissue of vitamin B-6-deficient rats. Material and Methods: The rats were divided into control and vitamin B-6-deficient groups. After 4 weeks of feeding, animals in all groups were anesthetized by thiopental sodium (50 mg/kg). Thoraces were opened, 2 mL blood samples were taken from aortas, then the rats were killed by cervical dislocation, and kidney tissues were removed. Biochemical measurements in kidney tissue were carried out using a spectrophotometer. Results: Total superoxide scavenger activity (TSSA), nonenzymatic superoxide scavenger activity (NSSA), superoxide dismutase (SOD) activities, and antioxidant potential (AOP) values in the vitamin B-6-deficient group were significantly lower than those of the control group, whereas glutathione peroxidase (GSH-Px), glutathione reductase (GRD), glutathione-S-transferase (GST) activities, and malondialdehyde (MDA) level were significantly higher than those of the control group (p < 0.05). Discussion: The results show that vitamin B-6 deficiency causes an attenuation in antioxidant defense system and an increase in oxidative stress in kidney tissue of rats.

Anahtar kelimeler

LIPID-PEROXIDATION ANTIOXIDANT ENZYMES Antioxidant potential vitamin B-6 deficiency vitamin

Atıf için künye

Keles, M., AL, B., Gumustekin, K., Demircan, B., ÖZBEY, İ., Akyuz, M., YILMAZ, A., Demir, E., Uyanık, A., ZİYPAK, T., & TAYSI, S. (2010). Antioxidative status and lipid peroxidation in kidney tissue of rats fed with vitamin B-6-deficient diet. Renal failure, 32(5), 618–622. https://doi.org/10.3109/0886022x.2010.481737

BibTeX 
@article{keles2010-227948,
  author = {Keles, Mustafa and AL, BEHÇET and Gumustekin, Kenan and Demircan, Berna and ÖZBEY, İsa and Akyuz, Mehmet and YILMAZ, ADNAN and Demir, Elif and Uyanık, Abdullah and ZİYPAK, Tevfik and TAYSI, SEYİTHAN},
  title = {Antioxidative status and lipid peroxidation in kidney tissue of rats fed with vitamin B-6-deficient diet},
  journal = {Renal failure},
  year = {2010},
  volume = {32},
  number = {5},
  pages = {618--622},
  issn = {0886-022X},
  doi = {10.3109/0886022x.2010.481737},
  url = {https://akademik.atauni.edu.tr/yayinlar/227948-antioxidative-status-and-lipid-peroxidation-in-kidney-tissue-of-rats-fed-with}
}