The clinical features, treatment and prognosis of neutropenic fever and Coronavirus disease 2019 results of the multicentre teos study

Başkol Elik, Dilşah; Kaya, Şafak; Alkan, Sevil; Demirdal, Tuna; Sener, Alper; Kaya, Selçuk; Güzel Tunçcan, Özlem; Kayaaslan, Bircan; Güner, Rahmet; Eser, Fatma; Kahraman, Hasip; Birengel, Serhat; Sarıcaoğlu, Elif Mukime; Eroğlu, Esma; Çölkesen, Fatma; Öztürk, Erman; Berk Cam, Hande; Mermutluoğlu, Çiğdem; Özer Balin, Şafak; Sincan, Gülden; Altın, Nilgün; Sili, Uluhan; Suntur, Bedia Mutay; Arslan Gülen, Tuğba; Deveci, Burak; Saba, Rabin; İncecik, Şaban; Eser Karlıdağ, Gülden; Hakko, Elif; Akdağ, Damla; Erdem, Hüseyin Aytaç; Sipahi, Hilal; Çicek, Candan; Taşbakan, Mehmet Sezai; Taşbakan, Meltem; Pullukçu, Hüsnü; Yamazhan, Tansu; Arda, Bilgin; Ulusoy, Sercan; Sipahi, Oguz Resat

doi:10.1038/s41598-024-55886-w

Makale Tam Makale Uluslararası 2024 Açık erişimli

The clinical features, treatment and prognosis of neutropenic fever and Coronavirus disease 2019 results of the multicentre teos study

Dilşah Başkol Elik, Şafak Kaya, Sevil Alkan, Tuna Demirdal, Alper Sener, Selçuk Kaya, Özlem Güzel Tunçcan, Bircan Kayaaslan, Rahmet Güner, Fatma Eser, Hasip Kahraman, Serhat Birengel, Elif Mukime Sarıcaoğlu, Esma Eroğlu, Fatma Çölkesen, Erman Öztürk, Hande Berk Cam, Çiğdem Mermutluoğlu, Şafak Özer Balin, Gülden Sincan, Nilgün Altın, Uluhan Sili, Bedia Mutay Suntur, Tuğba Arslan Gülen, Burak Deveci, Rabin Saba, Şaban İncecik, Gülden Eser Karlıdağ, Elif Hakko, Damla Akdağ, Hüseyin Aytaç Erdem, Hilal Sipahi, Candan Çicek, Mehmet Sezai Taşbakan, Meltem Taşbakan, Hüsnü Pullukçu, Tansu Yamazhan, Bilgin Arda, Sercan Ulusoy, Oguz Resat Sipahi

SCIENTIFIC REPORTS Cilt 14 · Sayı 1 · 01.12.2024

DOI ile aç

Özet

This multicentre (22 centres in Turkey) retrospective cohort study aimed to assess the clinical outcomes of patients with neutropenic fever and SARS-CoV-2 positivity. Study period was 15 March 2020–15 August 2021. A total of 170 cases (58 female, aged 59 ± 15.5 years) that fulfilled the inclusion criteria were included in the study. One-month mortality rate (OMM) was 44.8%. The logistic regression analysis showed the following significant variables for the mentioned dependent variables: (i) achieving PCR negativity: receiving a maximum of 5 days of favipiravir (p = 0.005, OR 5.166, 95% CI 1.639–16.280); (ii) need for ICU: receiving glycopeptide therapy at any time during the COVID-19/FEN episode (p = 0.001, OR 6.566, 95% CI 2.137–20.172), the need for mechanical ventilation (p < 0.001, OR 62.042, 95% CI 9.528–404.011); (iii) need for mechanical ventilation: failure to recover from neutropenia (p < 0.001, OR 17.869, 95% CI 3.592–88.907), receiving tocilizumab therapy (p = 0.028, OR 32.227, 95% CI 1.469–707.053), septic shock (p = 0.001, OR 15.4 96% CI 3.164–75.897), and the need for ICU (p < 0.001, OR 91.818, 95% CI 15.360–548.873), (iv) OMM: [mechanical ventilation (p = 0.001, OR 19.041, 95% CI 3.229–112.286) and septic shock (p = 0.010, OR 5.589,95% CI 1.509–20.700)]. Although it includes a relatively limited number of patients, our findings suggest that COVID-19 and FEN are associated with significant mortality and morbidity.

Sürdürülebilir Kalkınma Amaçları

SKA 3: Sağlıklı Bireyler

Atıf için künye

Başkol Elik, D., Kaya, Ş., Alkan, S., Demirdal, T., Sener, A., Kaya, S., Güzel Tunçcan, Ö., Kayaaslan, B., Güner, R., Eser, F., Kahraman, H., Birengel, S., Sarıcaoğlu, E. M., Eroğlu, E., Çölkesen, F., Öztürk, E., Berk Cam, H., Mermutluoğlu, Ç., Özer Balin, Ş., … Sipahi, O. R. (2024). The clinical features, treatment and prognosis of neutropenic fever and Coronavirus disease 2019 results of the multicentre teos study. SCIENTIFIC REPORTS, 14(1). https://doi.org/10.1038/s41598-024-55886-w

BibTeX

@article{baskolelik2024-227805,
  author = {Başkol Elik, Dilşah and Kaya, Şafak and Alkan, Sevil and Demirdal, Tuna and Sener, Alper and Kaya, Selçuk and Güzel Tunçcan, Özlem and Kayaaslan, Bircan and Güner, Rahmet and Eser, Fatma and Kahraman, Hasip and Birengel, Serhat and Sarıcaoğlu, Elif Mukime and Eroğlu, Esma and Çölkesen, Fatma and Öztürk, Erman and Berk Cam, Hande and Mermutluoğlu, Çiğdem and Özer Balin, Şafak and Sincan, Gülden and Altın, Nilgün and Sili, Uluhan and Suntur, Bedia Mutay and Arslan Gülen, Tuğba and Deveci, Burak and Saba, Rabin and İncecik, Şaban and Eser Karlıdağ, Gülden and Hakko, Elif and Akdağ, Damla and Erdem, Hüseyin Aytaç and Sipahi, Hilal and Çicek, Candan and Taşbakan, Mehmet Sezai and Taşbakan, Meltem and Pullukçu, Hüsnü and Yamazhan, Tansu and Arda, Bilgin and Ulusoy, Sercan and Sipahi, Oguz Resat},
  title = {The clinical features, treatment and prognosis of neutropenic fever and Coronavirus disease 2019 results of the multicentre teos study},
  journal = {SCIENTIFIC REPORTS},
  year = {2024},
  volume = {14},
  number = {1},
  issn = {2045-2322},
  doi = {10.1038/s41598-024-55886-w},
  url = {https://akademik.atauni.edu.tr/yayinlar/227805-the-clinical-features-treatment-and-prognosis-of-neutropenic-fever-and}
}