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Makale Tam Makale Uluslararası 2020 Açık erişimli

Role of Endothelin 1 on Proliferation and Migration of Human MCF-7 Cells

Irfan Cinar, Muhammed Yayla, Muhammet Çelik, Arzu Bilen, Zafer Bayraktutan

EURASIAN JOURNAL OF MEDICINE Cilt 52 · ss. 277–282 · 01.10.2020
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Özet

Objective: The aim of this study was to explore the role of endothelin 1 (ET-1) in human breast cancer proliferation and migration and antagonism of endothelin receptor A (ETAR) and endothelin receptor B (ETBR) by using the non-selective dual ETA/ETB receptor antagonist bosentan and determine its anti-proliferative, anti-metastatic, and apoptotic effects demonstrated by nuclear factor kappa B (NF-kB), vascular endothelial growth factor (VEGF), Caspase 3 and Caspase 9 expression on endothelin-induced proliferation of MCF-7 cell line in vitro.

Anahtar kelimeler

BONE EXPRESSION CANCER GROWTH MECHANISMS metastasis BOSENTAN ET-1 TUMOR MCF-7 HUMAN BREAST-CANCER B RECEPTOR

Sürdürülebilir Kalkınma Amaçları

  • SKA 3: Sağlıklı Bireyler

Atıf için künye

Cinar, I., Yayla, M., Çelik, M., Bilen, A., & Bayraktutan, Z. (2020). Role of Endothelin 1 on Proliferation and Migration of Human MCF-7 Cells. EURASIAN JOURNAL OF MEDICINE, 52, 277–282. https://doi.org/10.5152/eurasianjmed.2020.20033

BibTeX 
@article{cinar2020-227712,
  author = {Cinar, Irfan and Yayla, Muhammed and Çelik, Muhammet and Bilen, Arzu and Bayraktutan, Zafer},
  title = {Role of Endothelin 1 on Proliferation and Migration of Human MCF-7 Cells},
  journal = {EURASIAN JOURNAL OF MEDICINE},
  year = {2020},
  volume = {52},
  pages = {277--282},
  issn = {1308-8734},
  doi = {10.5152/eurasianjmed.2020.20033},
  url = {https://akademik.atauni.edu.tr/yayinlar/227712-role-of-endothelin-1-on-proliferation-and-migration-of-human-mcf-7-cells}
}