The relationship between NLRP3 rs10159239 and Vaspin rs2236242 gene variants and obstructive sleep apnea
Özet
Background: In obstructive sleep apnea (OSA), recurrent upper airway obstruction and apnea/hypopnea episodes result in endothelial dysfunction, which leads to the release of many proinflammatory cytokines and reactive oxygen species (ROS). ROS induces NLRP3, a protein involved in the synthesis of interleukin (IL)-1 and IL-18; vaspin is a serine protease inhibitor that has an important role in suppressing the activation of NLRP3 inflammasome. In this study, we aimed to investigate the effect of NLRP3 rs10159239 (rs9239) and vaspin rs2236242 (rs6242) single nucleotide polymorphisms (SNPs) on OSA development.
Anahtar kelimeler
Atıf için künye
KERGET, B., Kerget, F., Yüce Kahraman, Ç., Aksakal, A., & Araz, Ö. (2021). The relationship between NLRP3 rs10159239 and Vaspin rs2236242 gene variants and obstructive sleep apnea. UPSALA JOURNAL OF MEDICAL SCIENCES, 126(1), 7603. https://doi.org/10.48101/ujms.v126.7603
BibTeX
@article{kerget2021-227264,
author = {KERGET, Buğra and Kerget, Ferhan and Yüce Kahraman, Çiğdem and Aksakal, Alperen and Araz, Ömer},
title = {The relationship between NLRP3 rs10159239 and Vaspin rs2236242 gene variants and obstructive sleep apnea},
journal = {UPSALA JOURNAL OF MEDICAL SCIENCES},
year = {2021},
volume = {126},
number = {1},
issn = {0300-9734},
doi = {10.48101/ujms.v126.7603},
url = {https://akademik.atauni.edu.tr/yayinlar/227264-the-relationship-between-nlrp3-rs10159239-and-vaspin-rs2236242-gene-variants-and}
}