Distinct characteristics of asthma overlap phenotypes: Insights from the Turkish adult asthma registry
Özet
Introductıon: Considerable overlaps exist between asthma phenotypes and the clinical significance of these overlaps remains undetermined. The objective of this study is to analyze the characteristics of asthma overlap phenotypes using data from the Turkish Adult Asthma Registry (TAAR). Methods: This cross-sectional registry study included 2053 adult patients (74.8% female) with asthma. Results: Overall, 39.3% (n = 697) had allergic–eosinophilic (AE), 26.0% (n = 461) had allergic–non-eosinophilic (ANE), 21.3% (n = 377) had non-allergic–eosinophilic (NAE), and 13.4% (n = 237) had non-allergic–non-eosinophilic (NANE) asthma. Severe asthma exacerbations and emergency department (ED) visits were more frequent in the AE (28.3%, 31.2%, respectively) and NAE groups (36.0%, 34.0%, respectively) than in the ANE (14.3%, 20.6%, respectively) and NANE groups (12.6%, 16.7%, respectively) (p < 0.001). FEV1 values were significantly lower in the AE group than in the ANE and NANE groups (p < 0.001, p = 0.048, respectively) and in the NAE group than in the ANE group (p < 0.001). Risk factors for poor asthma control included living in rural areas, asthma-related ED visits, FEV1 < 60% in the NAE; being overweight, chronic rhinosinusitis, oral corticosteroids use, age < 40 years in the NANE; FEV1 < 80% in the AE; and severe asthma exacerbations, ED visits for AE and ANE groups. Conclusıon: The considerable overlap between allergic and eosinophilic asthma phenotypes has clinical implications as increased rates of asthma exacerbations and healthcare utilization. The clinical heterogeneity among asthma phenotypes based on a single biomarker highlights the importance of multidimensional asthma phenotyping.
Anahtar kelimeler
Atıf için künye
Kepil Ozdemir, S., GEMİCİOĞLU, B., Yildiz, F., HAYME, S., Alpagat, G., BOZKURT, N., Bulut, I., Erdinc, M., KARAKAYA, G., Keren, M., Pacaci Cetin, G., Yilmaz, I., Yorgancioglu, A., Aydin, O., Gokmen, D., Koycu Buhari, G., Celebi Sozener, Z., Beyaz, S., Orcen, C., … Celik, G. E. (2025). Distinct characteristics of asthma overlap phenotypes: Insights from the Turkish adult asthma registry. JOURNAL OF ASTHMA, 62(9), 1512–1524. https://doi.org/10.1080/02770903.2025.2493134
BibTeX
@article{kepilozdemir2025-227152,
author = {Kepil Ozdemir, Secil and GEMİCİOĞLU, BİLUN and Yildiz, Fusun and HAYME, SERHAT and Alpagat, Gulistan and BOZKURT, NURGÜL and Bulut, Ismet and Erdinc, Munevver and KARAKAYA, GÜL and Keren, Metin and Pacaci Cetin, Gulden and Yilmaz, Insu and Yorgancioglu, Arzu and Aydin, Omur and Gokmen, Derya and Koycu Buhari, Gozde and Celebi Sozener, Zeynep and Beyaz, Sengul and Orcen, Cihan and Damadoglu, Ebru and Yakut, Tugce and Kalpaklioglu, Ayse Fusun and Baccioglu, Ayse and Yalim, Sumeyra Alan and Koca Kalkan, Ilkay and Uysal, Mehmet Atilla and Ozgun Niksarlioglu, Elif Yelda and Kalyoncu, Ali Fuat and Erbay, Muge and Nayci, Sibel and Tepetam, Fatma Merve and Gelincik, Aslı and Dirol, Hulya and Goksel, Ozlem and Karaoglanoglu, Selen and Oner Erkekol, Ferda and Isik, Sacide Rana and Yavuz, Yasemin and Karadogan, Dilek and Seker, Ummuhan and Oguzulgen, Ipek Kivilcim and Basyigit, Ilknur and Argun Baris, Serap and Yılmazel Uçar, Elif and Erdogan, Tuba and Polatli, Mehmet and Ediger, Dane and Gunaydin, Fatma Esra and Turk, Murat and Pur, Leyla and Yegin Katran, Zeynep and Sekibag, Yonca and Aykac, Enes Furkan and Mungan, Dilsad and Gul, Ozcan and Cengiz, Ali and Akkurt, Bulent and Ozden, Seyma and Demir, Semra and Unal, Derya and Aslan, Ayse Feyza and Can, Ali and Gumusburun, Reyhan and Bogatekin, Gulhan and Akten, Hatice Serpil and Inan, Sinem and Ogus, Aliye Candan and Kavas, Murat and Polat Yulug, Demet and Cakmak, Mehmet Erdem and Kaya, Saltuk Bugra and Ozgur, Eylem Sercan and Uzun, Oguz and Tas Gulen, Sule and Pekbak, Gulseren and Kizilirmak, Deniz and Havlucu, Yavuz and Donmez, Halil and Arslan, Bahar and Soyyigit, Sadan and Yilmaz Kara, Bilge and Pasaoglu Karakis, Gulden and Dursun, Adile Berna and Kendirlinan, Resat and Ozturk, Ayse Bilge and Sevinc, Can and Omeroglu Simsek, Gokcen and Abadoglu, Oznur and Cerci, Pamir and Yucel, Taskin and Yorulmaz, Irfan and Tezcaner, Zahide Ciler and Cadalli Tatar, Emel and Suslu, Ahmet Emre and Ozer, Serdar and Dursun, Engin and Celik, Gulfem Elif},
title = {Distinct characteristics of asthma overlap phenotypes: Insights from the Turkish adult asthma registry},
journal = {JOURNAL OF ASTHMA},
year = {2025},
volume = {62},
number = {9},
pages = {1512--1524},
issn = {0277-0903},
doi = {10.1080/02770903.2025.2493134},
url = {https://akademik.atauni.edu.tr/yayinlar/227152-distinct-characteristics-of-asthma-overlap-phenotypes-insights-from-the-turkish}
}