Asthma patients with obesity have a unique phenotype: a subanalysis of the Turkish adult asthma registry
Özet
Objective: The obese-asthma phenotype has gradually increased in the last few years. We aimed to assess the differences between obese and non-obese patients with asthma. Methods: This research is a subanalysis of the Turkish Adult Asthma Registry (TAAR). Clinical presentation, disease control, severity, and demographics of obese and non-obese (normal-weight, overweight) patients were compared. Results: The obesity rate in TAAR was 32.2% (n = 619/1919; 18-83 years; 527 F/92 M). Patients with asthma and obesity had higher rates of childhood obesity, longer symptom duration, later onset of asthma, and more severe asthma. These patients were more likely to be female, older, less educated, and live in rural areas. Patients with obesity had more scheduled visits and emergency visits compared with non-obese patients, but similar asthma control, oral corticosteroid use, hospitalizations, intensive care unit admissions, and unscheduled visits. They also had a higher frequency of T2-high but lower frequency of possible T2-low phenotypes compared with normal-weight asthmatics. The risk of severe asthma in patients with obesity was 6.04 times higher for allergic than non-allergic patients and 3.58 times higher for the T2-high phenotype than for possible T2-low phenotypes. A one-unit increase in the asthma control test reduced the risk of severe asthma by 22%. Conclusions: A good definition of this phenotype is important to ensure that appropriate treatment strategies are implemented to achieve the control goal. We also believe that prevention of childhood obesity is an effective and pivotal strategy to achieve the goal of asthma control.
Anahtar kelimeler
Atıf için künye
ÇELEBİ SÖZENER, Z., OĞUZÜLGEN, İ. K., Ozalp Ates, F. S., Baccioglu, A., ARGUN BARIŞ, S., EDİGER, D., Gunaydın, F. E., SEVİNÇ, C., ŞEKER, Ü., Yılmaz Kara, B., Beyaz, S., Mungan, D., Aydin, O., Gokmen, D., Buhari, G. K., Gemicioglu, B., Bulut, I., Orcen, C., Kepil Ozdemir, S., … Celik, G. E. (2025). Asthma patients with obesity have a unique phenotype: a subanalysis of the Turkish adult asthma registry. JOURNAL OF ASTHMA, 62(7), 1183–1194. https://doi.org/10.1080/02770903.2025.2466182
BibTeX
@article{celebisozener2025-227133,
author = {ÇELEBİ SÖZENER, ZEYNEP and OĞUZÜLGEN, İPEK KIVILCIM and Ozalp Ates, Funda Seher and Baccioglu, Ayse and ARGUN BARIŞ, SERAP and EDİGER, DANE and Gunaydın, Fatma Esra and SEVİNÇ, CAN and ŞEKER, ÜMMÜHAN and Yılmaz Kara, Bilge and Beyaz, Sengul and Mungan, Dilsad and Aydin, Omur and Gokmen, Derya and Buhari, Gozde Koycu and Gemicioglu, Bilun and Bulut, Ismet and Orcen, Cihan and Kepil Ozdemir, Secil and Keren, Metin and Damadoglu, Ebru and Yakut, Tugce and Kalpaklioglu, Ayse Fusun and Alan Yalim, Sumeyra and Yilmaz, Insu and Koca Kalkan, Ilkay and Uysal, Mehmet Atilla and Ozgun Niksarlioglu, Elif Yelda and Kalyoncu, Ali Fuat and Karakaya, Gul and Erbay, Muge and Nayci, Sibel and Tepetam, Fatma Merve and Akkor Gelincik, Asli and Dirol, Hulya and Goksel, Ozlem and Karaoglanoglu, Selen and Oner Erkekol, Ferda and Isik, Sacide Rana and Yildiz, Fusun and Yavuz, Yasemin and Karadogan, Dilek and Bozkurt, Nurgul and Basyigit, Ilknur and Yılmazel Uçar, Elif and Erdogan, Tuba and Polatli, Mehmet and Turk, Murat and Pur, Leyla and Yegin Katran, Zeynep and Sekibag, Yonca and Aykac, Enes Furkan and Gul, Ozcan and Cengiz, Ali and Akkurt, Bulent and Ozden, Seyma and Demir, Semra and Unal, Derya and Aslan, Ayse Feyza and Can, Ali and Gumusburun, Reyhan and Bogatekin, Gulhan and Akten, Hatice Serpil and Inan, Sinem and Erdinc, Munevver and Ogus, Aliye Candan and Kavas, Murat and Polat Yulug, Demet and Cakmak, Mehmet Erdem and Kaya, Saltuk Bugra and Alpagat, Gulistan and Ozgur, Eylem Sercan and Uzun, Oguz and Gulen, Sule Tas and Pekbak, Gulseren and Kizilirmak, Deniz and Havlucu, Yavuz and Donmez, Halil and Arslan, Bahar and Cetin, Gulden Pacaci and Soyyigit, Sadan and Pasaoglu Karakis, Gulden and Dursun, Adile Berna and Kendirlinan, Resat and Ozturk, Ayse Bilge and Omeroglu Simsek, Gokcen and Abadoglu, Oznur and Cerci, Pamir and Yucel, Taskin and Yorulmaz, Irfan and Tezcaner, Zahide Ciler and Cadalli Tatar, Emel and Suslu, Ahmet Emre and Ozer, Serdar and Dursun, Engin and Yorgancioglu, Arzu and Celik, Gulfem Elif},
title = {Asthma patients with obesity have a unique phenotype: a subanalysis of the Turkish adult asthma registry},
journal = {JOURNAL OF ASTHMA},
year = {2025},
volume = {62},
number = {7},
pages = {1183--1194},
issn = {0277-0903},
doi = {10.1080/02770903.2025.2466182},
url = {https://akademik.atauni.edu.tr/yayinlar/227133-asthma-patients-with-obesity-have-a-unique-phenotype-a-subanalysis-of-the}
}