Trends in prescribing montelukast in patients with asthma in real-life: Results from the Turkish adult asthma registry
Özet
Montelukast, a leukotriene receptor antagonist (LTRA) approved for the treatment of asthma and allergic rhinitis, is widely used, though real-world data on its application in asthma management remain limited. This registry-based study evaluated the use of montelukast in adult asthma patients, examining demographic and disease characteristics, asthma control status, asthma phenotypes, presence of atopy, and treatment regimens. Among 2053 patients analyzed, 61.76% (n = 1268; mean age: 46.2 +/- 14.3 years), predominantly females (similar to 76%), received montelukast. Montelukast users showed higher rates of allergic rhinitis (P < 0.001), hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) (P = 0.008), and chronic rhinosinusitis (P = 0.008). Montelukast group also had higher atopy and total IgE levels and tended to be more eosinophilic. Montelukast was commonly preferred in allergic, eosinophilic, NSAID-exacerbated respiratory disease, and severe asthma phenotypes (P < 0.001). Patients receiving Steps 4 and 5 treatments are more likely to be prescribed montelukast (P < 0.001). Montelukast usage was higher among patients with uncontrolled asthma [ACT< 20 (OR:1.29, 95%CI:1.052-1.582, P = 0.014)]. In addition, logistic regression analyses identified the main factors associated with increased montelukast use as; female gender (OR:1.33, 95%CI:1.041-1.713, P = 0.02), presence of atopy (OR:1.46, 95%CI:1.157-1.864, P = 0.002), comorbid allergic rhinitis (OR:2.12, 95%CI:1.679-2.293, P < 0.001), and severe asthma (OR:2.18, 95%CI:1.712-2.784, P < 0.001). These findings reveal that montelukast use is prevalent among asthma patients, particularly in females, middle-aged adults, and those with comorbid allergic rhinitis, uncontrolled asthma, or specific asthma phenotypes, underscoring the factors that influence its prescription in asthma management. (c) 2025 Codon Publications. Published by Codon Publications.
Sürdürülebilir Kalkınma Amaçları
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SKA 3: Sağlıklı Bireyler
Atıf için künye
Beyaz, S., Erdinc, M., HAYME, S., ASLAN, A. F., Aydin, O., Gokmen, D., Buhari, G. K., ÇELEBİ SÖZENER, Z., GEMİCİOĞLU, B., Bulut, I., Orcen, C., Ozdemir, S. K., Keren, M., Damadoglu, E., Yakut, T., Kalpaklioglu, A. F., Baccioglu, A., Yalim, S. A., Yilmaz, I., … Celik, G. E. (2025). Trends in prescribing montelukast in patients with asthma in real-life: Results from the Turkish adult asthma registry. Allergologia et immunopathologia, 53(1), 12–25. https://doi.org/10.15586/aei.v53i1.1183
BibTeX
@article{beyaz2025-227129,
author = {Beyaz, Senguel and Erdinc, Munevver and HAYME, SERHAT and ASLAN, Ayşe Feyza and Aydin, Omur and Gokmen, Derya and Buhari, Goezde Koeycue and ÇELEBİ SÖZENER, ZEYNEP and GEMİCİOĞLU, BİLUN and Bulut, Ismet and Orcen, Cihan and Ozdemir, Secil Kepil and Keren, Metin and Damadoglu, Ebru and Yakut, Tugce and Kalpaklioglu, Ayse Fuesun and Baccioglu, Ayse and Yalim, Suemeyra Alan and Yilmaz, Insu and Kalkan, Ilkay Koca and Uysal, Mehmet Atilla and Niksarlioglu, Elif Yelda Ozgun and Kalyoncu, Ali Fuat and Karakaya, Gul and Erbay, Muge and Nayci, Sibel and Tepetam, Fatma Merve and Gelincik, Asli Akkor and Dirol, Hulya and Goksel, Ozlem and Karaoglanoglu, Selen and Erkekol, Ferda Oner and Isik, Sacide Rana and Yildiz, Fusun and Yavuz, Yasemin and Karadogan, Dilek and Bozkurt, Nurgul and Seker, Ummuhan and Oguzulgen, Ipek Kivilcim and Basyigit, Ilknur and Baris, Serap Argun and Yılmazel Uçar, Elif and Erdogan, Tuba and Polatli, Mehmet and Ediger, Dane and Gunaydin, Fatma Esra and Turk, Murat and Pur, Leyla and Katran, Zeynep Yegin and Sekibag, Yonca and Aykac, Enes Furkan and Mungan, Dilsad and Gul, Ozcan and Cengiz, Ali and Akkurt, Bulent and Ozden, Seyma and Demir, Semra and Unal, Derya and Can, Ali and Guemuesburun, Reyhan and Bogatekin, Guelhan and Akten, Hatice Serpil and Inan, Sinem and Ogus, Aliye Candan and Kavas, Murat and Yulug, Demet Polat and Cakmak, Mehmet Erdem and Kaya, Saltuk Bugra and Alpagat, Guelistan and Ozgur, Eylem Sercan and Uzun, Oguz and Gulen, Sule Tas and Pekbak, Gulseren and Kizilirmak, Deniz and Havlucu, Yavuz and Doenmez, Halil and Arslan, Bahar and Cetin, Gulden Pacaci and Soyyigit, Sadan and Kara, Bilge Yilmaz and Karakis, Gulden Pasaoglu and Dursun, Adile Berna and Kendirlinan, Resat and Ozturk, Ayse Bilge and Sevinc, Can and Simsek, Gokcen Omeroglu and Abadoglu, Oznur and Cerci, Pamir and Yucel, Taskin and Yorulmaz, Irfan and Tezcaner, Zahide Ciler and Tatar, Emel Cadalli and Suslu, Ahmet Emre and Ozer, Serdar and Dursun, Engin and Yorgancioglu, Arzu and Celik, Gulfem Elif},
title = {Trends in prescribing montelukast in patients with asthma in real-life: Results from the Turkish adult asthma registry},
journal = {Allergologia et immunopathologia},
year = {2025},
volume = {53},
number = {1},
pages = {12--25},
issn = {0301-0546},
doi = {10.15586/aei.v53i1.1183},
url = {https://akademik.atauni.edu.tr/yayinlar/227129-trends-in-prescribing-montelukast-in-patients-with-asthma-in-real-life-results}
}