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Frequency of Direct Oral Anticoagulants Usage in Acute Pulmonary Thromboembolism Treatment in Turkey (TUPEDO)

Elif Tanriverdi, NURİ TUTAR, Aysegul Senturk, Ayse Bahadir, Nimet Aksel, NUR ALEYNA YETKİN, Gulistan Karadeniz, Nazli Cetin, Ali Tabaru, Binnaz Zeynep Yildirim, HADİCE SELİMOĞLU ŞEN, NESLİHAN ÖZÇELİK, Emine Ozsari, Fatih Uzer, Tugba Cicek, Dorina Esendagli, Iclal Hocanli, Nagihan Durmus Kocak, Utku Tapan, Bahar Kurt, Sibel Arinc, Murat Kavas, Fusun Sahin, Dilek Ergun, Elif Yılmazel Uçar, TALAT KILIÇ, İNCİ GÜLMEZ, Julide Celdir Emre, Deniz Dogan, Fatma Ozdemir, Mustafa Duger, Suha Alzafer, Esra Yarar, Damla Serce Unat, Bilge Salik

Balkan Medical Journal Cilt 39 · Sayı 2 · ss. 148–152 · 01.03.2022
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Özet

Background: Direct oral anticoagulants (DOACs) have been used in acute pulmonary thromboembolism as an alternative to warfarin due to drug interactions, narrow therapeutic range, and necessary close International Normalized Ratio (INR) monitoring. Phase 3 study results have reported that these drugs are at least as effective as warfarin and beneficial in terms of bleeding; however, studies that present up-to-date life data are necessary. Aims: To evaluate the frequency of using DOACs, which are prescribed with a limited number of indications in our country, and real-life data results. Study Design: Cross-sectional study Methods: This cross-sectional survey collected the clinical data (history, current treatment, treatment duration, etc.) of patients with pulmonary thromboembolism and who applied to the physician for follow-up between October 15, 2019, and March 15, 2020. The researchers kept the patient records sequentially. Results: Data from 836 patients with acute pulmonary thromboembolism from 25 centers were collected, and DOAC was used in 320 (38.5%) of them. The most preferred DOAC was rivaroxaban (n = 294, 91.9%). DOAC was mostly preferred because it could not provide an effective INR level with warfarin (n=133, 41.6%). Bleeding was observed in 13 (4%) patients. Conclusion: The use of direct oral anticoagulants is becoming almost as widespread as conventional therapy. Real-life data results are important for their contribution to clinical practice.

Atıf için künye

Tanriverdi, E., TUTAR, N., Senturk, A., Bahadir, A., Aksel, N., YETKİN, N. A., Karadeniz, G., Cetin, N., Tabaru, A., Yildirim, B. Z., ŞEN, H. S., ÖZÇELİK, N., Ozsari, E., Uzer, F., Cicek, T., Esendagli, D., Hocanli, I., Kocak, N. D., Tapan, U., … Salik, B. (2022). Frequency of Direct Oral Anticoagulants Usage in Acute Pulmonary Thromboembolism Treatment in Turkey (TUPEDO). Balkan Medical Journal, 39(2), 148–152. https://doi.org/10.4274/balkanmedj.galenos.2021.2021-10-19

BibTeX 
@article{tanriverdi2022-227107,
  author = {Tanriverdi, Elif and TUTAR, NURİ and Senturk, Aysegul and Bahadir, Ayse and Aksel, Nimet and YETKİN, NUR ALEYNA and Karadeniz, Gulistan and Cetin, Nazli and Tabaru, Ali and Yildirim, Binnaz Zeynep and ŞEN, HADİCE SELİMOĞLU and ÖZÇELİK, NESLİHAN and Ozsari, Emine and Uzer, Fatih and Cicek, Tugba and Esendagli, Dorina and Hocanli, Iclal and Kocak, Nagihan Durmus and Tapan, Utku and Kurt, Bahar and Arinc, Sibel and Kavas, Murat and Sahin, Fusun and Ergun, Dilek and Yılmazel Uçar, Elif and KILIÇ, TALAT and GÜLMEZ, İNCİ and Emre, Julide Celdir and Dogan, Deniz and Ozdemir, Fatma and Duger, Mustafa and Alzafer, Suha and Yarar, Esra and Unat, Damla Serce and Salik, Bilge},
  title = {Frequency of Direct Oral Anticoagulants Usage in Acute Pulmonary Thromboembolism Treatment in Turkey (TUPEDO)},
  journal = {Balkan Medical Journal},
  year = {2022},
  volume = {39},
  number = {2},
  pages = {148--152},
  issn = {2146-3123},
  doi = {10.4274/balkanmedj.galenos.2021.2021-10-19},
  url = {https://akademik.atauni.edu.tr/yayinlar/227107-frequency-of-direct-oral-anticoagulants-usage-in-acute-pulmonary-thromboembolism}
}