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Makale Tam Makale Uluslararası 2021

The impact of COVID-19 on familial Mediterranean fever: a nationwide study

ZAFER GÜNENDİ, Fatma Gul Yurdakul, Hatice Bodur, Ahmet Kivanc Cengiz, Ulku Ucar, Hasan Fatih Cay, Nesrin Sen, Yaşar KESKİN, GÜLCAN GÜRER, Meltem Alkan Melikoğlu, Duygu ALTINTAŞ, HÜLYA DEVECİ, Merve Baykul, Kemal Nas, REMZİ ÇEVİK, ALİ YAVUZ KARAHAN, Murat Toprak, Sertac Ketenci, Mehmet Nayimoglu, İLHAN SEZER, Ali Nail Demir, Hilal Ecesoy, MEHMET TUNCAY DURUÖZ, Ozan Volkan YURDAKUL, AYŞE BANU SARIFAKIOĞLU, Sebnem Ataman

RHEUMATOLOGY INTERNATIONAL Cilt 41 · Sayı 8 · ss. 1447–1455 · 01.08.2021
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Özet

The study aimed to evaluate the impact of the coronavirus disease 2019 (COVID-19) in patients with familial Mediterranean fever (FMF) and to assess the relationships between FMF characteristics and severe COVID-19 outcomes such as hospitalization. The study was planned within a national network of 21 different centers. Demographics, FMF-related clinical and genetic characteristics, and COVID-19 outcomes were obtained. A total of 822 patients with FMF (mean age of 36 years) were included in the study. Fifty-nine of them (7%) had a COVID-19 diagnosis confirmed by real-time PCR test or chest CT findings. Most FMF patients with COVID-19 (58) had mild and moderate disease activity. All patients were on colchicine treatment. However, 8 of them (13.6%) were not compliant with colchicine use and 9 of them (15.3%) were colchicine resistant. Twelve FMF patients with COVID-19 were hospitalized. There were 4 patients requiring oxygen support. COVID-19 related complications were observed in 2 patients (1 thromboembolism, 1 acute respiratory distress syndrome). Hospitalized COVID-19 patients with FMF were older than non-hospitalized patients (median ages: 51 and 31 years, respectively; p: 0.002). Other FMF-related characteristics were similar between the groups. FMF-related characteristics were not found to be associated with poor outcomes in COVID-19. Thus, FMF may not be a risk factor for poor COVID-19 outcomes.

Anahtar kelimeler

COVID-19 hospitalization Familial Mediterranean fever Rheumatic diseases Colchicine Poor outcomes

Sürdürülebilir Kalkınma Amaçları

  • SKA 3: Sağlıklı Bireyler

Atıf için künye

GÜNENDİ, Z., Yurdakul, F. G., Bodur, H., Cengiz, A. K., Ucar, U., Cay, H. F., Sen, N., KESKİN, Y., GÜRER, G., Alkan Melikoğlu, M., ALTINTAŞ, D., DEVECİ, H., Baykul, M., Nas, K., ÇEVİK, R., KARAHAN, A. Y., Toprak, M., Ketenci, S., Nayimoglu, M., … Ataman, S. (2021). The impact of COVID-19 on familial Mediterranean fever: a nationwide study. RHEUMATOLOGY INTERNATIONAL, 41(8), 1447–1455. https://doi.org/10.1007/s00296-021-04892-6

BibTeX 
@article{gunendi2021-226208,
  author = {GÜNENDİ, ZAFER and Yurdakul, Fatma Gul and Bodur, Hatice and Cengiz, Ahmet Kivanc and Ucar, Ulku and Cay, Hasan Fatih and Sen, Nesrin and KESKİN, Yaşar and GÜRER, GÜLCAN and Alkan Melikoğlu, Meltem and ALTINTAŞ, Duygu and DEVECİ, HÜLYA and Baykul, Merve and Nas, Kemal and ÇEVİK, REMZİ and KARAHAN, ALİ YAVUZ and Toprak, Murat and Ketenci, Sertac and Nayimoglu, Mehmet and SEZER, İLHAN and Demir, Ali Nail and Ecesoy, Hilal and DURUÖZ, MEHMET TUNCAY and YURDAKUL, Ozan Volkan and SARIFAKIOĞLU, AYŞE BANU and Ataman, Sebnem},
  title = {The impact of COVID-19 on familial Mediterranean fever: a nationwide study},
  journal = {RHEUMATOLOGY INTERNATIONAL},
  year = {2021},
  volume = {41},
  number = {8},
  pages = {1447--1455},
  issn = {0172-8172},
  doi = {10.1007/s00296-021-04892-6},
  url = {https://akademik.atauni.edu.tr/yayinlar/226208-the-impact-of-covid-19-on-familial-mediterranean-fever-a-nationwide-study}
}