Predictive Factors for HBsAg Seroconversion Following Acute Hepatitis B Virus Infection: A Multicenter BUHASDER Study

Caydasi, Ozge; Engin, Derya Öztürk; Karaşahin, Ömer; Batırel, Ayşe; DOLU, SÜLEYMAN; Deniz, Müge Toygar; AKHAN, SILA; Özden, Kemalettin; Tosun, Selma; Sarıkaya, Burak; Görenek, Levent; Aydoğdu, Merve Çelik; Arslan, Eyüp; Karadağ, Fatma Yılmaz; Erol, Serpil; Ekinci, Semiha Çelik; Şahin, Ahmet; Özgüler, Müge; Atasoy, Pınar Yürük; Seyman, Derya; Yıldırım, Süleyman; Hakim, Gözde Derviş; Çakırca, Tuba Damar; Saral, Özlem Bayraktar; Sarı, Tuğba; Kaygusuz, Türkkan Öztürk; Günay, Süleyman; Köse, Şükran

doi:10.3390/v17091182

Makale Tam Makale Uluslararası 2025

Predictive Factors for HBsAg Seroconversion Following Acute Hepatitis B Virus Infection: A Multicenter BUHASDER Study

Ozge Caydasi, Derya Öztürk Engin, Ömer Karaşahin, Ayşe Batırel, SÜLEYMAN DOLU, Müge Toygar Deniz, SILA AKHAN, Kemalettin Özden, Selma Tosun, Burak Sarıkaya, Levent Görenek, Merve Çelik Aydoğdu, Eyüp Arslan, Fatma Yılmaz Karadağ, Serpil Erol, Semiha Çelik Ekinci, Ahmet Şahin, Müge Özgüler, Pınar Yürük Atasoy, Derya Seyman, Süleyman Yıldırım, Gözde Derviş Hakim, Tuba Damar Çakırca, Özlem Bayraktar Saral, Tuğba Sarı, Türkkan Öztürk Kaygusuz, Süleyman Günay, Şükran Köse

Viruses Cilt 17 · Sayı 9 · 01.09.2025

DOI ile aç

Özet

Experience with the effect of antiviral therapy on HBsAg seroconversion in acute hepatitis B is limited. We aimed to evaluate the factors affecting HBsAg seroconversion in patients with acute hepatitis B (AHB) receiving antiviral treatment. We performed a retrospective and multicenter study involving 107 adult patients who received antiviral treatment for AHB between January 2018 and December 2024. The median age was 48 (min–max, 18–91) years, and 66.3% of the patients were male; 70 patients with 24-week follow-up (15 patients without HBsAg seroconversion versus 55 patients with HBsAg seroconversion) were compared based on HBsAg seroconversion status. Multivariate logistic regression analysis revealed that age was independently associated with HBsAg seroconversion (odds ratio = 0.926; 95% confidence interval (CI) 0.874 to 0.981; p = 0.009). A one-year increase in age was associated with a 0.926-fold decrease in HBsAg seroconversion. In conclusion, age was an independent predictor of HBsAg seroconversion following acute hepatitis B virus infection.

Anahtar kelimeler

acute hepatitis B entecavir HBsAg seroconversion predictor tenofovir

Atıf için künye

Caydasi, O., Engin, D. Ö., Karaşahin, Ö., Batırel, A., DOLU, S., Deniz, M. T., AKHAN, S., Özden, K., Tosun, S., Sarıkaya, B., Görenek, L., Aydoğdu, M. Ç., Arslan, E., Karadağ, F. Y., Erol, S., Ekinci, S. Ç., Şahin, A., Özgüler, M., Atasoy, P. Y., … Köse, Ş. (2025). Predictive Factors for HBsAg Seroconversion Following Acute Hepatitis B Virus Infection: A Multicenter BUHASDER Study. Viruses, 17(9). https://doi.org/10.3390/v17091182

BibTeX

@article{caydasi2025-225336,
  author = {Caydasi, Ozge and Engin, Derya Öztürk and Karaşahin, Ömer and Batırel, Ayşe and DOLU, SÜLEYMAN and Deniz, Müge Toygar and AKHAN, SILA and Özden, Kemalettin and Tosun, Selma and Sarıkaya, Burak and Görenek, Levent and Aydoğdu, Merve Çelik and Arslan, Eyüp and Karadağ, Fatma Yılmaz and Erol, Serpil and Ekinci, Semiha Çelik and Şahin, Ahmet and Özgüler, Müge and Atasoy, Pınar Yürük and Seyman, Derya and Yıldırım, Süleyman and Hakim, Gözde Derviş and Çakırca, Tuba Damar and Saral, Özlem Bayraktar and Sarı, Tuğba and Kaygusuz, Türkkan Öztürk and Günay, Süleyman and Köse, Şükran},
  title = {Predictive Factors for HBsAg Seroconversion Following Acute Hepatitis B Virus Infection: A Multicenter BUHASDER Study},
  journal = {Viruses},
  year = {2025},
  volume = {17},
  number = {9},
  issn = {1999-4915},
  doi = {10.3390/v17091182},
  url = {https://akademik.atauni.edu.tr/yayinlar/225336-predictive-factors-for-hbsag-seroconversion-following-acute-hepatitis-b-virus}
}