Atatürk Üniversitesi Atatürk Üniversitesi
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Makale Tam Makale Uluslararası 2026

Cancer prevalence and prognosis among individuals living with HIV and AIDS in Turkey: Multicenter BUHASDER study

ÖZLEM GÜLER, SILA AKHAN, Atahan Çağatay, Ayşe Batırel, Elif Sargın Altunok, Sibel Bolukçu, Hülya Özkan Özdemir, Emine İlay Duman, MÜGE TOYGAR DENİZ, Derya Özyiğitoğlu, Kemalettin Özden, Handan Alay, Derya Seyman, Melda Türken, Şebnem Çalık, Özge Çaydaşı, Derya Öztürk Engin, Özgür Günal, Şeyma Topal, Oğuz Karabay, Figen Sarıgül, Hanife Nur Karakoç Parlayan, Ayşin Kılınç Toker, Özlem Aydın, Emre Bayhan, Pınar Ergen, Nevin İnce, Şafak Kaya, Selcan Arslan Özel, Aybegüm Özşahin, Esra Gürbüz, Ahmet Şahin, Sibel Balcı, Şükran Köse

International Journal of STD and AIDS Cilt 37 · Sayı 5 · ss. 500–510 · 01.04.2026
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Özet

Background: This multicentre study evaluated the prevalence, distribution, and risk factors of cancer among people living with HIV (PLWH) in Turkey over two decades. Mortality rates and factors were also investigated. Methods: This retrospective cohort study included 154 adults diagnosed with cancer and HIV between 2008 and 2024. Data were collected from the medical records. The demographics, clinical characteristics, cancer types, treatments, and outcomes were evaluated. The risk factors for ADCs and mortality were defined using multivariate logistic regression and Cox regression. The estimated survival time was determined using Kaplan-Meier analysis. Results: Among 8708 PLWH, cancer prevalence was 1.8% (95% CI:1.5-2). ADCs (66.9%) were twice as frequent as NADCs (33.1%). Most prevalent cancers were non-Hodgkin lymphoma (35.1%), Kaposi sarcoma (29.9%), and lung cancer (7.8%). Age ≤54 years, CD4 + T lymphocyte count ≤94/mm3, and HHV-8 co-infection were risk factors for ADCs. Mortality rate was 32%. Non-Hodgkin lymphoma and CD4 + T lymphocyte count ≤232/mm3at treatment completion predicted mortality. The 3-years overall survival rate was 67.6%. Conclusions: This study offers insights into cancer burden among PLWH in Turkey. High rates of ADCs and mortality highlight the importance of early HIV diagnosis and antiretroviral therapy access to reduce cancer burden in this population.

Anahtar kelimeler

CANCER Mortality HIV malignancy acquired immunodeficiency syndrome

Atıf için künye

GÜLER, Ö., AKHAN, S., Çağatay, A., Batırel, A., Sargın Altunok, E., Bolukçu, S., Özkan Özdemir, H., Duman, E. İ., TOYGAR DENİZ, M., Özyiğitoğlu, D., Özden, K., Alay, H., Seyman, D., Türken, M., Çalık, Ş., Çaydaşı, Ö., Öztürk Engin, D., Günal, Ö., Topal, Ş., … Köse, Ş. (2026). Cancer prevalence and prognosis among individuals living with HIV and AIDS in Turkey: Multicenter BUHASDER study. International Journal of STD and AIDS, 37(5), 500–510. https://doi.org/10.1177/09564624251405965

BibTeX 
@article{guler2026-225322,
  author = {GÜLER, ÖZLEM and AKHAN, SILA and Çağatay, Atahan and Batırel, Ayşe and Sargın Altunok, Elif and Bolukçu, Sibel and Özkan Özdemir, Hülya and Duman, Emine İlay and TOYGAR DENİZ, MÜGE and Özyiğitoğlu, Derya and Özden, Kemalettin and Alay, Handan and Seyman, Derya and Türken, Melda and Çalık, Şebnem and Çaydaşı, Özge and Öztürk Engin, Derya and Günal, Özgür and Topal, Şeyma and Karabay, Oğuz and Sarıgül, Figen and Karakoç Parlayan, Hanife Nur and Kılınç Toker, Ayşin and Aydın, Özlem and Bayhan, Emre and Ergen, Pınar and İnce, Nevin and Kaya, Şafak and Arslan Özel, Selcan and Özşahin, Aybegüm and Gürbüz, Esra and Şahin, Ahmet and Balcı, Sibel and Köse, Şükran},
  title = {Cancer prevalence and prognosis among individuals living with HIV and AIDS in Turkey: Multicenter BUHASDER study},
  journal = {International Journal of STD and AIDS},
  year = {2026},
  volume = {37},
  number = {5},
  pages = {500--510},
  issn = {0956-4624},
  doi = {10.1177/09564624251405965},
  url = {https://akademik.atauni.edu.tr/yayinlar/225322-cancer-prevalence-and-prognosis-among-individuals-living-with-hiv-and-aids-in}
}