Understanding clinical outcomes and factors influencing mortality in intensive care unit patients with COVID-19-associated candidemia
Özet
Background: During the COVID pandemic, research has shown an increase in candidemia cases following severe COVID infection and the identification of risk factors associated with candidemia. However, there is a lack of studies that specifically explore clinical outcomes and mortality rates related to candidemia after COVID infection.Objectives: The aim of this international study was to evaluate the clinical outcomes and identify factors influencing mortality in patients who developed candidemia during their COVID infection.Patients/Methods: This study included adult patients (18 years of age or older) admitted to the intensive care unit (ICU) and diagnosed with COVID-associated candidemia (CAC). The research was conducted through ID-IRI network and in collaboration with 34 medical centres across 18 countries retrospectively, spanning from the beginning of the COVID pandemic until December 2021.Results: A total of 293 patients diagnosed with CAC were included. The median age of the patients was 67, and 63% of them were male. The most common Candida species detected was C. albicans. The crude 30-day mortality rate was recorded at 62.4%. The logistic regression analysis identified several factors significantly impacting mortality, including age (odds ratio [OR] 1.04, 95% confidence interval [CI] 1.02-1.07, p < .0005), SOFA score (OR 1.307, 95% CI 1.17-1.45, p < .0005), invasive mechanical ventilation (OR 7.95, 95% CI 1.44-43.83, p < .017) and duration of mechanical ventilation (OR 0.98, 95% CI 0.96-0.99, p < .020).Conclusions: By recognising these prognostic factors, medical professionals can customise their treatment approaches to offer more targeted care, leading to improved patient outcomes and higher survival rates for individuals with COVID-associated candidemia.
Sürdürülebilir Kalkınma Amaçları
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SKA 3: Sağlıklı Bireyler
Atıf için künye
Aydın, S., Mert, A., Yılmaz, M., Al Maslamani, M., Rahimi, B. A., Ayoade, F., El-Kholy, A., Belitova, M., Sengel, B. E., Jalal, S., Albayrak, A., Alatawi, J. A., Szabo, B. G., Ganeshan, R. S., Nsutebu, E., Poojary, A., Akkoyunlu, Y., Alkan, S., Elik, D. B., … Erdem, H. (2024). Understanding clinical outcomes and factors influencing mortality in intensive care unit patients with COVID-19-associated candidemia. MYCOSES, 67(1). https://doi.org/10.1111/myc.13687
BibTeX
@article{aydin2024-225101,
author = {Aydın, Selda and Mert, Ali and Yılmaz, Mesut and Al Maslamani, Muna and Rahimi, Bilal Ahmad and Ayoade, Folusakin and El-Kholy, Amani and Belitova, Maya and Sengel, Buket Erturk and Jalal, Sabah and Albayrak, Ayşe and Alatawi, Jamayel Adnan and Szabo, Balint Gergely and Ganeshan, Ramesh Shankar and Nsutebu, Emmanuel and Poojary, Aruna and Akkoyunlu, Yasemin and Alkan, Sevil and Elik, Dilsah Baskol and Eser-Karlidag, Gulden and Santos, Lurdes and Moroti, Ruxandra and Altin, Nilguen and Guerbuez, Esra and Ulusoy, Tuelay Uenver and Sipahi, Oguz Resat and Caskurlu, Huelya and Esmaoglu, Aliye and Lakatos, Botond and El-Sayed, Nagwa Mostafa and Marino, Andrea and Cascio, Antonio and Mihai, Alexandru and Dumitru, Irina Magdalena and Pshenichnaya, Natalia and Ripon, Rezaul Karim and Makek, Mateja Jankovic and Rashid, Naveed and Baljic, Rusmir and Dascalu, Cosmin and Sincan, Gülden and Kizmaz, Yesim Uygun and Madendere, Berk and Erdem, Hakan},
title = {Understanding clinical outcomes and factors influencing mortality in intensive care unit patients with COVID-19-associated candidemia},
journal = {MYCOSES},
year = {2024},
volume = {67},
number = {1},
issn = {0933-7407},
doi = {10.1111/myc.13687},
url = {https://akademik.atauni.edu.tr/yayinlar/225101-understanding-clinical-outcomes-and-factors-influencing-mortality-in-intensive}
}