A multicentre prospective analysis of the incidence of pemphigoid diseases in Turkey
Özet
Background The differentiation between the pemphigoid diseases is essential for treatment and prognosis. In Turkey, data on the incidence of these diseases are insufficient. Our aim in this study is to determine the incidence, demographics and clinical characteristics associated with diseases of the pemphigoid group. Methods We prospectively analysed 295 patients with pemphigoid who visited dermatology clinics of tertiary referral hospitals in 12 different regions of Turkey within a year. The diagnosis was based on clinical, histopathological, direct immunofluorescence (DIF) and serological (multivariant enzyme-linked immunosorbent assay [ELISA], indirect immunofluorescence and mosaic-based BIOCHIP) examinations. Clinical and demographic findings, aetiological factors and concomitant diseases observed in the patients were recorded. Results A total of 295 (female/male ratio: 1.7/1) patients with pemphigoid were diagnosed in 1-year period. The overall incidence rate of pemphigoid diseases was found to be 3.55 cases per million-years. The ratio of pemphigoid group diseases to pemphigus group diseases was 1.6. The most common pemphigoid type was bullous pemphigoid (BP, 93.2%). The others were epidermolysis bullosa acquisita (3.1%), pemphigoid gestationis (2.4%), linear IgA disease (1%) and mucous membrane pemphigoid (0.3%). The most common (26.8%) possible trigger of the bullous pemphigoid was gliptin derivative drugs. The most common concomitant diseases with pemphigoid were cardiovascular (27.8%) and neurological diseases (23.7%). Conclusions This study showed that the increased frequency of bullous pemphigoid reversed the pemphigoid/pemphigus ratio in Turkey. Further studies are warranted regarding the reasons for this increase.
Anahtar kelimeler
Atıf için künye
Durdu, M., Bozca, B. C., Enli, S., Yazici Ozgen, Z., Yaylı, S., Aktan, Ş., Mutlu, D., Erturan, İ., Ayvaz Çelik, H. H., Melikoğlu, M., Pala, E., Gursel Urun, Y., Harman, M., Bozkurt Şavk, E., Isik, S., Duygulu, S., Imren, I. G., Fettahlıoğlu Karaman, B., Kaya Erdoğan, H., … Uzun, S. (2021). A multicentre prospective analysis of the incidence of pemphigoid diseases in Turkey. AUSTRALASIAN JOURNAL OF DERMATOLOGY, 62(4). https://doi.org/10.1111/ajd.13731
BibTeX
@article{durdu2021-224637,
author = {Durdu, Murat and Bozca, Burcin Cansu and Enli, Servinaz and Yazici Ozgen, Zuleyha and Yaylı, Savaş and Aktan, Şebnem and Mutlu, Derya and Erturan, İjlal and Ayvaz Çelik, Havva Hilal and Melikoğlu, Mehmet and Pala, Erdal and Gursel Urun, Yildiz and Harman, Mehmet and Bozkurt Şavk, Ekin and Isik, Selin and Duygulu, Seniz and Imren, Isil Gogem and Fettahlıoğlu Karaman, Bilge and Kaya Erdoğan, Hilal and Kılıç, Arzu and Ozcelik, Sinan and Inan, Kiymet and Yilmaz, Mustafa Anil and Sanli, Hatice Erdi and Kalay Yildizhan, Incilay and Mülayim, Mehmet Kamil and Cicek, Demet and Demir, Betul and Yasak Güner, Rukiye and Baykal Selçuk, Leyla and Gündüz, Kamer and Daye, Munise and Borlu, Murat and Öksüm Solak, Eda and Dizman, Didem and Güneş, Begüm and Ozkur, Ezgi and Polat, Mualla and Eskiocak, Ali Haydar and Uzun, Soner},
title = {A multicentre prospective analysis of the incidence of pemphigoid diseases in Turkey},
journal = {AUSTRALASIAN JOURNAL OF DERMATOLOGY},
year = {2021},
volume = {62},
number = {4},
issn = {0004-8380},
doi = {10.1111/ajd.13731},
url = {https://akademik.atauni.edu.tr/yayinlar/224637-a-multicentre-prospective-analysis-of-the-incidence-of-pemphigoid-diseases-in}
}