DETERMINATION OF ANTIOXIDANT ACTIVITY OF HIPPOPHAERHAMNOIDES L. GROWING IN TURKEY AND INVESTIGATION OFITS EFFECTS ON THE LIVER TOXICITY IN RATS
Özet
Objective: The goal of the present work was to investigate the antioxidant properties of the extracts
of Hippophae rhamnoides L. and to determine their effects on liver toxicity in rats.
Material and Method: Metal chelation, reducing power and DPPH radical scavenging methods
were used in the antioxidant activity analysis of extracts. The total phenolic content was determined
using the folin-ciocalteu reagent. Plant extracts were administered orally to the rats at doses of 500
µg/kg for 2 days. Each animal group was composed of six female Albino Wistar rats with an average
weight of 250 g. Microscopic examination was carried out to observe any pathological changes in
the rat livers.
Result and Discussion: Water extract showed the highest radical scavenging activity (48.65%),
reducing power (0.291 absorbance at 700 nm) and metal chelating (35.40%) at 1 mg/ml
concentration. Histopathological studies showed that especially water extract reduced the severity
of CCl4-induced intoxication. Hippophae rhamnoides L. extracts were found to have antioxidant
activity, and also Hippophae rhamnoides L. water extract was shown to be particularly effective in
preventing liver damage.
Atıf için künye
Çapa, M., Kadıoğlu, Y., Çadırcı, E., & Albayrak, M. (2024). DETERMINATION OF ANTIOXIDANT ACTIVITY OF HIPPOPHAERHAMNOIDES L. GROWING IN TURKEY AND INVESTIGATION OFITS EFFECTS ON THE LIVER TOXICITY IN RATS. Ankara Universitesi Eczacilik Fakultesi Dergisi, 48(3), 1–12.
BibTeX
@article{capa2024-22382,
author = {Çapa, Metin and Kadıoğlu, Yücel and Çadırcı, Elif and Albayrak, Mevlüt},
title = {DETERMINATION OF ANTIOXIDANT ACTIVITY OF HIPPOPHAERHAMNOIDES L. GROWING IN TURKEY AND INVESTIGATION OFITS EFFECTS ON THE LIVER TOXICITY IN RATS},
journal = {Ankara Universitesi Eczacilik Fakultesi Dergisi},
year = {2024},
volume = {48},
number = {3},
pages = {1--12},
issn = {1015-3918},
url = {https://akademik.atauni.edu.tr/yayinlar/22382-determination-of-antioxidant-activity-of-hippophaerhamnoides-l-growing-in-turkey}
}