Spectrofluorimetric Determination of alpha-Tocopherol in Capsules and Human Plasma
Özet
A simple, sensitive and rapid spectrofluorimetric method for determination of alpha-tocopherol in pharmaceutical capsule and human plasma was developed and validated. The native fluorescence of alpha-tocopherol was measured at 334 nm with excitation at 291 nm, after extraction of alpha-tocopherol from human plasma hexane: dichloromethane mixture. The calibration curves were linear (R >= 0.9993) in the concentration range of 0.25-2.5 mu g/ml of alpha-tocopherol in both standard solutions and plasma samples. The developed method was directly and easily applied for determination of alpha-tocopherol in the plasma of healthy volunteers and different type of bladder cancer and stomach cancer patients and also pharmaceutical capsule.
Anahtar kelimeler
Sürdürülebilir Kalkınma Amaçları
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SKA 3: Sağlıklı Bireyler
Atıf için künye
Demirkaya Miloğlu, F., Kadıoğlu, Y., Şenol, O., & YAMAN, M. (2013). Spectrofluorimetric Determination of alpha-Tocopherol in Capsules and Human Plasma. INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 75(5), 563–568.
BibTeX
@article{demirkayamiloglu2013-22372,
author = {Demirkaya Miloğlu, Fatma and Kadıoğlu, Yücel and Şenol, Onur and YAMAN, Mustafa},
title = {Spectrofluorimetric Determination of alpha-Tocopherol in Capsules and Human Plasma},
journal = {INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES},
year = {2013},
volume = {75},
number = {5},
pages = {563--568},
issn = {0250-474X},
url = {https://akademik.atauni.edu.tr/yayinlar/22372-spectrofluorimetric-determination-of-alpha-tocopherol-in-capsules-and-human}
}