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Makale Tam Makale Uluslararası 2022

Multisystem inflammatory syndrome in children associated with COVID-19 in 101 cases from Turkey (Turk-MISC study)

Dilek Yilmaz Ciftdogan, Yildiz Ekemen Keles, Adem Karbuz, BENHUR ŞİRVAN ÇETİN, Sefika Elmas Bozdemir, EDA KEPENEKLİ KADAYİFCİ, Ozge Metin Akcan, Arife Ozer, Tugba Erat, Murat Sutcu, Ayse Buyukcam, NURŞEN BELET, Emine Hafize Erdeniz, Nazan Dalgic Karabulut, Selda Hancerli Torun, SELİM ÖNCEL, Zerrin Orbak, Özden TÜREL, ZEYNEP GÖKÇE GAYRETLİ AYDIN, ÖMER KILIÇ, Aysun Yahsi, Ahu Kara Aksay, Zeynep Ergenc, Mey Talip Petmezci, MEHMET BURHAN OFLAZ, Remzi Sarikaya, Gulcin Otar Yener, Seval Ozen, Doruk Gul, GAZİ ARSLAN, Soner Sertan Kara, Demet Demirkol, PINAR YAZICI ÖZKAYA, Yilmaz Yozgat, Celal Varan, Manolya Kara, GÜL ARGA, NURHAYAT YAKUT, Ahmet Osman Kilic, ÖZLEM ÇAKICI, Mehmet Kucuk, Ozge Kaba, HATİCE KARAOĞLU ASRAK, Burcu Bursal Duramaz, Tahir Dalkiran, Ayse Berna Anil, MEHMET TURĞUT, BÜLENT KARAPINAR, Ayper Somer, FERHAN ELMALI, ENER ÇAĞRI DİNLEYİCİ, ERGİN ÇİFTCİ, ATEŞ KARA

JOURNAL OF PAEDIATRICS AND CHILD HEALTH Cilt 58 · Sayı 6 · ss. 1069–1078 · 01.06.2022
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Özet

Aim Multisystem inflammatory syndrome in children (MIS-C) may cause shock and even death in children. The aim of this study is to describe the clinical features, laboratory characteristics and outcome of children diagnosed with MIS-C in 25 different hospitals in Turkey. Methods The retrospective study was conducted between 8 April and 28 October 2020 in 25 different hospitals from 17 cities. Data were collected from patients' medical records using a standardised form. Clinical and laboratory characteristics and outcomes according to different age groups, gender and body mass index percentiles were compared using multivariate logistic regression analysis. Results The study comprised 101 patients, median age 7 years (interquartile range (IQR) 4.6-9.3); 51 (50.5%) were boys. Reverse-transcriptase polymerase chain reaction (PCR) assay was positive in 21/100 (21%) patients; 62/83 (74.6%) patients had positive serology for SARS-CoV-2. The predominant complaints were fever (100%), fatigue (n = 90, 89.1%), and gastrointestinal symptoms (n = 81, 80.2%). Serum C-reactive protein (in 101 patients, median 165 mg/L; range 112-228), erythrocyte sedimentation rate (73/84, median 53 mm/s; IQR 30-84) and procalcitonin levels (86/89, median 5 mu g/L; IQR 0.58-20.2) were elevated. Thirty-eight patients (37.6%) required admission to intensive care. Kawasaki disease (KD) was diagnosed in 70 (69.3%) patients, 40 of whom had classical KD. Most patients were treated with intravenous immunoglobulin (n = 92, 91%) and glucocorticoids (n = 59, 58.4%). Seven patients (6.9%) died. Conclusion The clinical spectrum of MIS-C is broad, but clinicians should consider MIS-C in the differential diagnosis when persistent fever, fatigue and gastrointestinal symptoms are prominent. Most patients diagnosed with MIS-C were previously healthy. Immunomodulatory treatment and supportive intensive care are important in the management of cases with MIS-C. Glucocorticoids and intravenous immunoglobulins are the most common immunomodulatory treatment options for MIS-C. Prompt diagnosis and prompt treatment are essential for optimal management.

Anahtar kelimeler

DIAGNOSIS child COVID-19 RECEPTOR MIS-C Kawasaki disease shock SARS

Sürdürülebilir Kalkınma Amaçları

  • SKA 3: Sağlıklı Bireyler
  • SKA 8: İnsana Yakışır İş ve Ekonomik Büyüme

Atıf için künye

Yilmaz Ciftdogan, D., Ekemen Keles, Y., Karbuz, A., ÇETİN, B. Ş., Elmas Bozdemir, S., KEPENEKLİ KADAYİFCİ, E., Metin Akcan, O., Ozer, A., Erat, T., Sutcu, M., Buyukcam, A., BELET, N., Erdeniz, E. H., Dalgic Karabulut, N., Hancerli Torun, S., ÖNCEL, S., Orbak, Z., TÜREL, Ö., GAYRETLİ AYDIN, Z. G., … KARA, A. (2022). Multisystem inflammatory syndrome in children associated with COVID-19 in 101 cases from Turkey (Turk-MISC study). JOURNAL OF PAEDIATRICS AND CHILD HEALTH, 58(6), 1069–1078. https://doi.org/10.1111/jpc.15913

BibTeX 
@article{yilmazciftdogan2022-223618,
  author = {Yilmaz Ciftdogan, Dilek and Ekemen Keles, Yildiz and Karbuz, Adem and ÇETİN, BENHUR ŞİRVAN and Elmas Bozdemir, Sefika and KEPENEKLİ KADAYİFCİ, EDA and Metin Akcan, Ozge and Ozer, Arife and Erat, Tugba and Sutcu, Murat and Buyukcam, Ayse and BELET, NURŞEN and Erdeniz, Emine Hafize and Dalgic Karabulut, Nazan and Hancerli Torun, Selda and ÖNCEL, SELİM and Orbak, Zerrin and TÜREL, Özden and GAYRETLİ AYDIN, ZEYNEP GÖKÇE and KILIÇ, ÖMER and Yahsi, Aysun and Kara Aksay, Ahu and Ergenc, Zeynep and Petmezci, Mey Talip and OFLAZ, MEHMET BURHAN and Sarikaya, Remzi and Otar Yener, Gulcin and Ozen, Seval and Gul, Doruk and ARSLAN, GAZİ and Kara, Soner Sertan and Demirkol, Demet and YAZICI ÖZKAYA, PINAR and Yozgat, Yilmaz and Varan, Celal and Kara, Manolya and ARGA, GÜL and YAKUT, NURHAYAT and Kilic, Ahmet Osman and ÇAKICI, ÖZLEM and Kucuk, Mehmet and Kaba, Ozge and KARAOĞLU ASRAK, HATİCE and Bursal Duramaz, Burcu and Dalkiran, Tahir and Berna Anil, Ayse and TURĞUT, MEHMET and KARAPINAR, BÜLENT and Somer, Ayper and ELMALI, FERHAN and DİNLEYİCİ, ENER ÇAĞRI and ÇİFTCİ, ERGİN and KARA, ATEŞ},
  title = {Multisystem inflammatory syndrome in children associated with COVID-19 in 101 cases from Turkey (Turk-MISC study)},
  journal = {JOURNAL OF PAEDIATRICS AND CHILD HEALTH},
  year = {2022},
  volume = {58},
  number = {6},
  pages = {1069--1078},
  issn = {1034-4810},
  doi = {10.1111/jpc.15913},
  url = {https://akademik.atauni.edu.tr/yayinlar/223618-multisystem-inflammatory-syndrome-in-children-associated-with-covid-19-in-101}
}