Carnitine metabolism in diabetes mellitus

Coker, M; Coker, C; Darcan, S; Can, S; Orbak, Zerrin; Goksen, D

doi:10.1515/jpem.2002.15.6.841

Makale Tam Makale Uluslararası 2002

Carnitine metabolism in diabetes mellitus

M Coker, C Coker, S Darcan, S Can, Zerrin Orbak, D Goksen

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM Cilt 15 · Sayı 6 · ss. 841–849 · 01.06.2002

DOI ile aç

Özet

In diabetes mellitus (DM), increased fatty acids have negative effects on pancreatic beta-cell functions, in addition to enhanced mitochondrial transportation of fatty acids related to decreased insulin levels. The aim of this study was to evaluate lipid metabolism in children with DM by measuring plasma fatty acids and carnitine fractions to reveal relationships between carnitine status and increased fatty acid oxidation. Increased plasma fatty acids (except for arachidonic acid, there were no significant differences in the ratio of each specific fatty acid to total fatty acids), lipoprotein (a), acyl carnitine levels and urinary total and free acyl carnitine excretion, and decreased plasma free carnitine levels, were found in children with DM. There were no correlations between the duration of DM or HbA(1c) and study parameters. It is recommended that plasma free carnitine determinations should be made even if the patient has good metabolic control.

Anahtar kelimeler

CHILDREN DIABETES-MELLITUS PLASMA Serum rats BLOOD INSULIN urine FATTY-ACIDS Carnitine lipoprotein (a) LIPOPROTEIN(A) CONCENTRATIONS GLUCOSE DISPOSAL NERVE-CONDUCTION PALMITOYLTRANSFERASE

Sürdürülebilir Kalkınma Amaçları

SKA 3: Sağlıklı Bireyler

Atıf için künye

Coker, M., Coker, C., Darcan, S., Can, S., Orbak, Z., & Goksen, D. (2002). Carnitine metabolism in diabetes mellitus. JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, 15(6), 841–849. https://doi.org/10.1515/jpem.2002.15.6.841

BibTeX

@article{coker2002-223553,
  author = {Coker, M and Coker, C and Darcan, S and Can, S and Orbak, Zerrin and Goksen, D},
  title = {Carnitine metabolism in diabetes mellitus},
  journal = {JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM},
  year = {2002},
  volume = {15},
  number = {6},
  pages = {841--849},
  issn = {0334-018X},
  doi = {10.1515/jpem.2002.15.6.841},
  url = {https://akademik.atauni.edu.tr/yayinlar/223553-carnitine-metabolism-in-diabetes-mellitus}
}