Clinical, Demographic, and Radiological Characteristics of Patients Demonstrating Antibodies Against Myelin Oligodendrocyte Glycoprotein
Özet
Background: Optic neuritis, myelitis, and neuromyelitis optica spectrum disorder (NMOSD) have been associated with antibodies against myelin oligodendrocyte glycoprotein-immunoglobulin G (anti-MOG-IgG). Furthermore, patients with radiological and demographic features atypical for multiple sclerosis (MS) with optic neuritis and myelitis also demonstrate antibodies against aquaporin-4 and anti-MOG-IgG. However, data on the diagnosis, treatment, follow-up, and prognosis in patients with anti-MOG-IgG are limited. Aims: To evaluate the clinical, radiological, and demographic characteristics of patients with anti-MOG-IgG. Study Design: Multicenter, retrospective, observational study. Methods: Patients with blood samples demonstrating anti-MOG-IgG that had been evaluated at the Neuroimmunology laboratory at Ondokuz May & imath;s University's Faculty of Medicine were included in the study. Results: Of the 104 patients with anti-MOG-IgG, 56.7% were women and43.3% were men. Approximately 2.4% of the patients were diagnosed with MS, 15.8% with acute disseminated encephalomyelitis (ADEM), 39.4% with NMOSD, 31.3% with isolated optic neuritis, and 11.1% with isolated myelitis. Approximately 53.1% of patients with spinal involvement at clinical onset demonstrated a clinical course of NMOSD. Thereafter, 8.8% of these patients demonstrated a clinical course similar to MS and ADEM, and 28.1% demonstrated a clinical course of isolated myelitis. The response to acute attack treatment was lower and the disability was higher in patients aged > 40 years than patients aged < 40 years at clinical onset. Oligoclonal band was detected in 15.5% of the patients. Conclusion: For patients with NMOSD and without anti-NMO antibodies, the diagnosis is supported by the presence of anti-MOG-IgG. Furthermore, advanced age at clinical onset, Expanded Disability Status Scale (EDSS) score at clinical onset, spinal cord involvement, and number of attacks may be negative prognostic factors in patients with anti-MOG-IgG.
Atıf için künye
Koc, S., Şen, S., Terzi, Y., KIZILAY, F., Demir, S., AKSOY, D., Kurtulus, F., Bilge, N., Idilman, E., Uzunkopru, C., Gungor, S., Cilingir, V., Ethemoglu, O., Boz, C., Gumus, H., Kilic, A. K., Kisabay, A., Bir, L. S., Turan, O. F., … Terzi, M. (2024). Clinical, Demographic, and Radiological Characteristics of Patients Demonstrating Antibodies Against Myelin Oligodendrocyte Glycoprotein. Balkan Medical Journal, 41(4), 272–279. https://doi.org/10.4274/balkanmedj.galenos.2024.2024-1-97
BibTeX
@article{koc2024-223187,
author = {Koc, Sumeyye and Şen, Sedat and Terzi, Yüksel and KIZILAY, FERAH and Demir, Serkan and AKSOY, DÜRDANE and Kurtulus, Fatma and Bilge, Nuray and Idilman, Egemen and Uzunkopru, Cihat and Gungor, Serdal and Cilingir, Vedat and Ethemoglu, Ozlem and Boz, Cavit and Gumus, Haluk and Kilic, Ahmet Kasim and Kisabay, Aysin and Bir, Levent Sinan and Turan, Omer Faruk and Soysal, Aysun and Koseoglu, Mesrure and Uzuner, Gulnur Tekgol and BAYINDIR, HASAN and Kabay, Sibel Canbaz and Cam, Mustafa and Yayla, Vildan and Tan, Hüseyin and Ozcan, Abdulcemal and Taskapioglu, Ozlem and Korkmaz, Muammer and Tamam, Yusuf and Inanc, Yilmaz and EFENDİ, HÜSNÜ and Kotan, Dilcan and YETKİN, MEHMET FATİH and Bilgic, Adnan Burak and SAÇMACI, HİKMET and Demirci, Serpil and Celik, Yahya and Poyraz, Turan and Terzi, Murat},
title = {Clinical, Demographic, and Radiological Characteristics of Patients Demonstrating Antibodies Against Myelin Oligodendrocyte Glycoprotein},
journal = {Balkan Medical Journal},
year = {2024},
volume = {41},
number = {4},
pages = {272--279},
issn = {2146-3123},
doi = {10.4274/balkanmedj.galenos.2024.2024-1-97},
url = {https://akademik.atauni.edu.tr/yayinlar/223187-clinical-demographic-and-radiological-characteristics-of-patients-demonstrating}
}