Acute Disseminated Encephalomyelitis in Children and Adolescents: A Multicenter Retrospective Study of Relapse and Outcome
Özet
Objectives: To evaluate the demographic, clinical, laboratory, and prognostic data of children with acute disseminated encephalomyelitis with respect to anti-myelin oligodendrocyte glycoprotein (MOG) antibody status. Methods: Acute disseminated encephalomyelitis patients (n = 245) from 24 centers followed up between 2010 and 2022 were evaluated retrospectively. The short- and long-term outcome characteristics (disease severity and course, clinical relapse, and recovery rates) were assessed. Incomplete clinical recovery was defined as modified Rankin Score ≥1 or the presence of epilepsy. Univariant and multivariant analysis were performed for outcome characteristics. Results: The mean age at diagnosis was 6.3 ± 3.8 (0.5-17.7) years and the median follow-up was 22 (3-132) months. The outcome characteristics were evaluated in 180 of 245 patients (73.4%) with at least 12 months’ follow-up. Twenty-three patients (12.6%) relapsed. The multivariable logistic regression analysis revealed the following clinical parameters as predictors of relapse: sex, visual impairment, and ataxia at initial presentation. Incomplete clinical recovery (n = 42/180, 23.3%) was associated with the presence of seizures on admission and the need for an intensive care unit. Anti-MOG antibody positivity was not associated with an increased risk of relapse (25% vs 13.1%, P =.164) or incomplete clinical recovery (P =.511). Conclusion: The nationwide cohort presented further supports the typically monophasic nature of acute disseminated encephalomyelitis, and a high rate of complete recovery. The presence of certain symptoms in the acute period may assist the clinician in estimating the outcome.
Anahtar kelimeler
Atıf için künye
Kanmaz, S., Yılmaz, S., Dündar, N. O., Aksoy, A., CANPOLAT, M., PER, H., Erol, İ., GÜMÜŞ, H., Özkale, Y., YILDIRIM, S., Toprak, D. E., Öncel, İ., Özkale, M., Mansur, E. N., Serin, H. M., Ersöz, G., Besen, Ş., Mert, G. G., Güleç, A., … Anlar, B. (2025). Acute Disseminated Encephalomyelitis in Children and Adolescents: A Multicenter Retrospective Study of Relapse and Outcome. Journal of child neurology, 40(10), 838–851. https://doi.org/10.1177/08830738251334219
BibTeX
@article{kanmaz2025-223147,
author = {Kanmaz, Seda and Yılmaz, Sanem and Dündar, Nihal Olgaç and Aksoy, Ayşe and CANPOLAT, MEHMET and PER, HÜSEYİN and Erol, İlknur and GÜMÜŞ, HAKAN and Özkale, Yasemin and YILDIRIM, SEMA and Toprak, Dilara Ece and Öncel, İbrahim and Özkale, Murat and Mansur, Elif Nurdan and Serin, Hepsen Mine and Ersöz, Gülşen and Besen, Şeyda and Mert, Gülen Gül and Güleç, Ayten and Şahin, Sevim and Ölçülü, Cemile Büşra and Selek, Ayberk and Pekuz, Serdar and Başarır, Günce and Günay, Çağatay and Biçer, Didem and Kahraman, Zehra Filiz and Yüksel, Deniz and Karadağ, Meral and Şimşek, Erdem and Ünalp, Aycan and Yıldız, Nihal and Direk, Meltem Çobanoğulları and Yiş, Uluç and Tan, Hüseyin and Havalı, Cengiz and Değerliyurt, Aydan and Güngör, Mesut and Hergüner, Özlem and Oncel, Elif Perihan and Ünver, Olcay and Kumandaş, Sefer and Celik, Hale Atalay and Özgör, Bilge and Cansu, Ali and Atasever, Aslı Kübra and Tosun, Ayşe and Güngör, Olcay and Okuyaz, Çetin and Edizer, Selvinaz and Hız, Semra and Sarıgeçili, Esra and Kayılıoğlu, Hülya and Yazgan, Ceren Durgun and Tuncer, Gökçen Öz and Gençpınar, Pınar and Yılmaz, Ünsal and Özgür, Su and Tekgül, Hasan and Anlar, Banu},
title = {Acute Disseminated Encephalomyelitis in Children and Adolescents: A Multicenter Retrospective Study of Relapse and Outcome},
journal = {Journal of child neurology},
year = {2025},
volume = {40},
number = {10},
pages = {838--851},
issn = {0883-0738},
doi = {10.1177/08830738251334219},
url = {https://akademik.atauni.edu.tr/yayinlar/223147-acute-disseminated-encephalomyelitis-in-children-and-adolescents-a-multicenter}
}