Atatürk Üniversitesi Atatürk Üniversitesi
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Makale Uluslararası 2021

Effect of cholecalciferol treatment on serum FGF-23, vitamin D-binding globulin and alpha-klotho levels in children with vitamin D deficiency

İlker Tosun, Zerrin Orbak, Hakan Döneray, Nurinnisa Öztürk

HORMONE RESEARCH IN PAEDIATRICS Cilt 94 · Sayı SUPPL 1 · ss. 225 · 01.09.2021

Özet

Introduction and Aim: FGF-23 is a hormone that works by

inhibiting phosphorus reabsorption in kidneys, and systematic

regulation of phosphate homeostasis by FGF23 depends on the

activity of the membrane protein Klotho. It affects the active vitamin level according to the bioactive free vitamin hypothesis, which

binds DVBP to vitamin D and prolongs its half-life. In this study,

it was aimed to investigate 1.25 (OH) Vitamin D, Vitamin D Binding Protein, FGF-23 and α-Klotho levels and how these parameters changed with the treatment of cholecalciferol in vitamin D

deficiency.

Method: Patients with rickets were included in the study.

Vitamin D, parathormone (PTH), calcium (Ca), phosphorus (P),

alkaline phosphatase (ALP), Fibroblast Growth Factor-23 (FGF23), α-Klotho, vitamin D binding protein (DVBP) levels in blood

samples were examined before and after the treatment. The study

was supported by Ataturk University Scientific Research Projects

Coordination Unit (BAP) with project number 7181.

Results: 16 children under the age of 2 were included in the

study. The average age was 8.57 ± 6.16 months. Two patients (13%)

applied to our clinic with the hypocalcemic seizure. While serum

Ca (p<0.001), P (p<0.001), vitamin D (p <0.01) levels significantly

increased, serum FGF-23 (p <0.05), PTH (p <0.01) and ALP levels

(p<0.01) significantly decreased after cholecalciferol treatment.

There was a positive correlation between serum FGF-23 and PTH

levels (p <0.05).

Conclusion: Serum Ca, P, ALP and PTH levels reached normal levels with cholecalciferol treatment. FGF-23, not α-Klotho

and vitamin D binding protein, plays an important role in rickets

pathophysiology

Sürdürülebilir Kalkınma Amaçları

  • SKA 8: İnsana Yakışır İş ve Ekonomik Büyüme

Atıf için künye

Tosun, İ., Orbak, Z., Döneray, H., & Öztürk, N. (2021). Effect of cholecalciferol treatment on serum FGF-23, vitamin D-binding globulin and alpha-klotho levels in children with vitamin D deficiency. HORMONE RESEARCH IN PAEDIATRICS, 94(SUPPL 1), 225.

BibTeX 
@article{tosun2021-222631,
  author = {Tosun, İlker and Orbak, Zerrin and Döneray, Hakan and Öztürk, Nurinnisa},
  title = {Effect of cholecalciferol treatment on serum FGF-23, vitamin D-binding globulin and alpha-klotho levels in children with vitamin D deficiency},
  journal = {HORMONE RESEARCH IN PAEDIATRICS},
  year = {2021},
  volume = {94},
  number = {SUPPL 1},
  pages = {225},
  issn = {1663-2818},
  url = {https://akademik.atauni.edu.tr/yayinlar/222631-effect-of-cholecalciferol-treatment-on-serum-fgf-23-vitamin-d-binding-globulin}
}