Determination of Naproxen using derivatization with MSTFA in pharmaceuticalpreparations by GC-MS method
Özet
This work reports the using of N-methyl-N-(trimethylsilyl) trifluoroacetamide for the derivatization of naproxen
and the GC-MS method for naproxen detection in pharmaceutical preparations. The linearity of the GC-MS
technique was proven over the concentration range of 0.5-12 µg/mL. There was less than 1.20 and 1.73% for the
intra- and inter-day relative standard deviation, respectively. For the GC-MS technique, the limits of detection
and quantification were established at 0.05 and 0.15 µg/mL. The developed technique was used to analysis
tablets of a pharmaceutical preparation called Aleve. At the chosen assay conditions, tablet excipients did not
cause any interference.
Atıf için künye
Yılmaz, B., Turan, Ö., Yılmaz, S., & Kadıoğlu, Y. (2024). Determination of Naproxen using derivatization with MSTFA in pharmaceuticalpreparations by GC-MS method. NanoEra, 4(1), 1–5. https://dergipark.org.tr/en/download/issue-file/79225
BibTeX
@article{yilmaz2024-22104,
author = {Yılmaz, Bilal and Turan, Ömer and Yılmaz, Semih and Kadıoğlu, Yücel},
title = {Determination of Naproxen using derivatization with MSTFA in pharmaceuticalpreparations by GC-MS method},
journal = {NanoEra},
year = {2024},
volume = {4},
number = {1},
pages = {1--5},
issn = {2792-0666},
url = {https://akademik.atauni.edu.tr/yayinlar/22104-determination-of-naproxen-using-derivatization-with-mstfa-in}
}