Determination and Pharmacokinetics of Mexiletine in Rabbit Plasma by Gas Chromatography with Mass Spectrometry
Özet
This paper describes a gas chromatography/mass spectrophotometry method for determination of mexiletine in rabbit plasma. Mexiletine and internal standard metoprolol were extracted from rabbit plasma with a mixture of ethylacetate and diethylether at basic pH with liquid-liquid extraction. Calibration curves were linear over the concentration range 45-2000ng/mL. Intra- and inter-day precision (relative standard deviation) for mexiletine in rabbit plasma were less than 6.9%, and accuracy (relative error) was better than 6.8%. Recovery of mexiletine from rabbit plasma averaged 92.6%. This method was successfully applied to six rabbits which had given an oral capsule of 200mg mexiletine.
Atıf için künye
Yılmaz, B. (2010). Determination and Pharmacokinetics of Mexiletine in Rabbit Plasma by Gas Chromatography with Mass Spectrometry. ANALYTICAL LETTERS, 43(16), 2534–2542. https://doi.org/10.1080/00032711003725623
BibTeX
@article{yilmaz2010-22047,
author = {Yılmaz, Bilal},
title = {Determination and Pharmacokinetics of Mexiletine in Rabbit Plasma by Gas Chromatography with Mass Spectrometry},
journal = {ANALYTICAL LETTERS},
year = {2010},
volume = {43},
number = {16},
pages = {2534--2542},
issn = {0003-2719},
doi = {10.1080/00032711003725623},
url = {https://akademik.atauni.edu.tr/yayinlar/22047-determination-and-pharmacokinetics-of-mexiletine-in-rabbit-plasma-by-gas}
}