Voltammetric behavior of carvedilol in non-aqueous media and its analytical determination in pharmaceutical preparations

In this study, a simple and reliable cyclic voltammetry and linear sweep voltammetry method were developed and validated for determination of carvedilol in pharmaceutical preparations. The proposed method was based on electrochemical oxidation of carvedilol at platinum electrode in acetonitrile solution containing 0.1 m TBAClO(4). The well defined three oxidation peaks were observed at 1.02, 1.17 and 1.42 V, respectively. Calibration curve that obtained by using current values measured for second peak was linear over the concentration range of 5-40 mu g/ml. Intra- and inter-day precision values for carvedilol were < 3.64 and accuracy (relative error) was better than 2.49%. The mean recovery of carvedilol was 99.8% for pharmaceutical preparations. The limits of detection and quantification were 1.32 and 4.00 mu g/ml, respectively. No interference was found from three tablet excipients at the selected assay conditions. The method developed in this study is accurate, precise and can be easily applied to Dilatrend, Carvexal and Coronis tablets as pharmaceutical preparation.