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Makale Tam Makale Uluslararası 2014

L-carnitine alleviates sciatic nerve crush injury in rats: functional and electron microscopy assessments

Ümmü Zeynep AVŞAR, Ümit AVŞAR, Ali Aydın, Muhammed Yayla, Berna Ozturkkaragoz, HARUN ÜN, Murat SARITEMUR, Tolga Mercantepe

NEURAL REGENERATION RESEARCH Cilt 9 · Sayı 10 · ss. 1020–1024 · 01.05.2014
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Özet

Several studies have demonstrated that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats with diabetes mellitus. It is hypothesized that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats. Rat sciatic nerve was crush injured by a forceps and exhibited degenerative changes. After intragastric administration of 50 and 100 mg/kg L-carnitine for 30 days, axon area, myelin sheath area, axon diameter, myelin sheath diameter, and numerical density of the myelinated axons of injured sciatic nerve were similar to normal, and the function of injured sciatic nerve also improved significantly. These findings suggest that L-camitine exhibits neuroprotective effects on sciatic nerve crush injury in rats.

Anahtar kelimeler

DYSFUNCTION oxidative stress REGENERATION antioxidant ALZHEIMERS-DISEASE NEUROPROTECTION Electron microscopy PROTECTS L-carnitine ACETYL-L-CARNITINE CONDUCTION Nerve regeneration sciatic nerve axon PERIPHERAL-NERVE INJURY crush injury myelin sheath neural regeneration L-ACETYLCARNITINE PROMOTES

Sürdürülebilir Kalkınma Amaçları

  • SKA 3: Sağlıklı Bireyler

Atıf için künye

AVŞAR, Ü. Z., AVŞAR, Ü., Aydın, A., Yayla, M., Ozturkkaragoz, B., ÜN, H., SARITEMUR, M., & Mercantepe, T. (2014). L-carnitine alleviates sciatic nerve crush injury in rats: functional and electron microscopy assessments. NEURAL REGENERATION RESEARCH, 9(10), 1020–1024. https://doi.org/10.4103/1673-5374.133163

BibTeX 
@article{avsar2014-219117,
  author = {AVŞAR, Ümmü Zeynep and AVŞAR, Ümit and Aydın, Ali and Yayla, Muhammed and Ozturkkaragoz, Berna and ÜN, HARUN and SARITEMUR, Murat and Mercantepe, Tolga},
  title = {L-carnitine alleviates sciatic nerve crush injury in rats: functional and electron microscopy assessments},
  journal = {NEURAL REGENERATION RESEARCH},
  year = {2014},
  volume = {9},
  number = {10},
  pages = {1020--1024},
  issn = {1673-5374},
  doi = {10.4103/1673-5374.133163},
  url = {https://akademik.atauni.edu.tr/yayinlar/219117-l-carnitine-alleviates-sciatic-nerve-crush-injury-in-rats-functional-and}
}